Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

Duo, Yanhong1,4; Xiang, Zhongyuan1; Gao, Ge2; Luo, Guanghong1,2,3; Tang, Ben Zhong5

2023-10-01

10.1016/j.trac.2023.117252

TRAC-TRENDS IN ANALYTICAL CHEMISTRY   影响因子和分区

0165-9936

1879-3142

Fluorescent biosensors are powerful analytical tools that have been widely employed in a range of in vitro and in vivo biomedical applications. However, traditional fluorophores exhibit aggregation-caused quenching (ACQs) effects that hinder their use in the development of more advanced fluorescent biosensors. The discovery by Prof. Ben Zhong Tang of aggregation-induced emission (AIE) luminogen (AIEgen) that exhibit effects opposite to those of fluorophores impacted by ACQ provides a range of unique opportunities for the design of novel "turn-on" biosensors. These AIEgens have thus attracted extensive interest from researchers seeking to leverage their properties to produce more effective biosensing molecules, biosensing strategies, and associated biomedical applications. A wide array of AIEgens with unique structures, functional groups, optical properties, and applications have been developed in recent years. In the present review, we provide a comprehensive overview of recent advances in the field of AIEgen-based fluorescent biosensor design and discuss the future clinical prospects of these molecules. Through these discussions, we hope to provide a strong evidence-based foundation for further efforts aimed at producing increasingly advanced AIEgen-based fluorescent biosensors.

Aggregation-induced emission Fluorescent biosensor Biomedical application

SCI

英语

通讯

National Natural Science Foundation of China[82102904] ; Natural Science Foundation of Guangdong Province[2020A1515010400] ; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20190807144605514","JCYJ20210324113405014","JCYJ20190808154213097"] ; Hunan Provincial Science and Technology Plan Project[2021SK5001]

Chemistry

Chemistry, Analytical

WOS:001095630800001

ELSEVIER SCI LTD

CHEMISTRY

Web of Science

1.Cent South Univ, Xiangya Hosp 2, Dept Lab Med, Changsha, Peoples R China
2.Cent South Univ, Xiangya Hosp 3, Dept Lab Med, Changsha, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Radiat Onco, Shenzhen 518020, Guangdong, Peoples R China
4.Harvard Univ, Wyss Inst Biolog Inspired Engn, Boston, MA 02138 USA
5.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

Duo, Yanhong,Xiang, Zhongyuan,Gao, Ge,et al. Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2023,167.

Duo, Yanhong,Xiang, Zhongyuan,Gao, Ge,Luo, Guanghong,&Tang, Ben Zhong.(2023).Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,167.

Duo, Yanhong,et al."Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 167(2023).