Self-calibrating dual-sensing electrochemical sensors for accurate detection of carbon dioxide in blood

Yang，Da1; An，Jia2; Qiu，Wu3; Gao，Yuhan1,2; Zhang，Jiajing1,4; Pan，Wencai5; Zhao，Peng6; Liu，Yufei1,4,7

2024

10.1007/s00604-023-06101-6

Microchimica Acta   影响因子和分区

0026-3672

1436-5073

A paper-based electrochemical dual-function biosensor capable of determining pH and TCO was synthesized for the first time using an iridium oxide pH electrode and an all-solid-state ion electrode (ASIE). In the study, to obtain highly reliable results, the biosensor was equipped with a real-time pH correction function before TCO measurements. Compared to traditional liquid-filling carbon dioxide detection sensors, the utilization of ferrocene endows our novel sensor with abundant positive sites, and thus greatly improves its performance. Conversely, the introduction of MXene with conductivity close to that of metals reduces electrode resistance, which is beneficial for accelerating the electrochemical reaction of the sensor and reducing LOD. After optimization, the detection range of TCO is 0.095 nM–0.66 M, with a detection limit of as low as 0.023 nM. In addition, the sensor was used in real serum sample-spiked recovery experiments and comparison experiments with existing clinical blood gas analyzers, which confirmed the effectiveness of its clinical application. This study provides a method for the rational design of paper-based electrochemical biosensors and a new approach for the clinical detection of blood carbon dioxide. Graphical abstract: [Figure not available: see fulltext.].

Differential pulse voltammetry Ion electrode Iridium oxide MXene Paper-based biosensor

SCI ; EI

英语

其他

2-s2.0-85179556366

Scopus

1.Key Laboratory of Optoelectronic Technology & Systems (Chongqing University),Ministry of Education,Chongqing,400044,China
2.School of Microelectronics,Southern University of Science and Technology,Shenzhen,518055,China
3.School of Rehabilitation Sciences and Engineering,University of Health and Rehabilitation Sciences,Qingdao,400015,China
4.Center for Intelligent Sensing Technology,College of Optoelectronic Engineering,Chongqing University,Chongqing,400044,China
5.Department of Medical Engineering,Xinqiao Hospital,Chongqing,183 Xinqiao Main Street,400037,China
6.National Innovation Center for Advanced Medical Devices,Shenzhen,40F, Huide Tower,518126,China
7.Faculty of Science and Engineering,Swansea University,Swansea,Singleton Park,SA2 8PP,United Kingdom

Yang，Da,An，Jia,Qiu，Wu,et al. Self-calibrating dual-sensing electrochemical sensors for accurate detection of carbon dioxide in blood[J]. Microchimica Acta,2024,191(1).

Yang，Da.,An，Jia.,Qiu，Wu.,Gao，Yuhan.,Zhang，Jiajing.,...&Liu，Yufei.(2024).Self-calibrating dual-sensing electrochemical sensors for accurate detection of carbon dioxide in blood.Microchimica Acta,191(1).

Yang，Da,et al."Self-calibrating dual-sensing electrochemical sensors for accurate detection of carbon dioxide in blood".Microchimica Acta 191.1(2024).