The association between periodontitis and hepatitis virus infection: a cross-sectional study utilizing data from the NHANES database (2003–2018)

Chen，X.1; Zeng，Z.2; Xiao，L.1

2024

10.1016/j.puhe.2023.11.005

Public Health   影响因子和分区

0033-3506

1476-5616

Objectives: Periodontitis and hepatitis virus infection significantly impact individuals' well-being and are prevalent public health concerns globally. Given the current scarcity of large-scale cross-sectional epidemiological studies, this study seeks to enrich the evidence base by examining the link between these two conditions. Study design and methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2003–2018. A multivariate logistic regression analysis was performed to assess the association between periodontitis and hepatitis virus infection, adjusting for the potential confounding factors. Subsequently, a stratified analysis was conducted to explore the relationship between periodontitis and hepatitis virus infection based on age, gender, race, marital status, alcohol consumption, smoking status, and the presence of chronic diseases. Results: In this study, which included 5755 participants, there was a positive association between hepatitis virus infection and periodontitis (odds ratio [OR]: 2.609 [95% confidence interval (CI): 1.513, 4.499]). Furthermore, a significant association was observed between moderate periodontitis and hepatitis virus infection (OR: 2.136 [95% CI: 1.194, 3.822]), and this association was even stronger for severe periodontitis (OR: 3.583 [95% CI: 1.779, 7.217]). Importantly, this positive association between hepatitis virus infection and periodontitis was consistent across different subgroups. Conclusions: This study presents evidence of a significant association between periodontitis and hepatitis virus infection. These findings highlight the crucial importance of integrating periodontal health and liver health considerations into public health interventions. Further research is necessary to elucidate the underlying mechanisms and develop targeted interventions for effectively managing periodontitis and hepatitis virus infection.

Hepatitis virus infection NHANES Periodontal disease Periodontitis Viral hepatitis

SCI ; SSCI

英语

其他

SOCIAL SCIENCES, GENERAL

2-s2.0-85178554789

Scopus

1.Department of Clinical Laboratory Medicine Center,Shenzhen Hospital,Southern Medical University,Shenzhen,Guangdong,518000,China
2.The First Affiliated Hospital(Shenzhen People's Hospital),Southern University of Science and Technology,Shenzhen,518055,China

Chen，X.,Zeng，Z.,Xiao，L.. The association between periodontitis and hepatitis virus infection: a cross-sectional study utilizing data from the NHANES database (2003–2018)[J]. Public Health,2024,226:114-121.

Chen，X.,Zeng，Z.,&Xiao，L..(2024).The association between periodontitis and hepatitis virus infection: a cross-sectional study utilizing data from the NHANES database (2003–2018).Public Health,226,114-121.

Chen，X.,et al."The association between periodontitis and hepatitis virus infection: a cross-sectional study utilizing data from the NHANES database (2003–2018)".Public Health 226(2024):114-121.