Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)

Tan，Dunyong1; Huang，Zeqi1; Zhao，Zhe1; Chen，Xiaoqiang1; Liu，Jianquan1; Wang，Daping1,2; Deng，Zhiqin1; Li，Wencui1

2024

10.3892/ijmm.2023.5326

International Journal of Molecular Medicine   影响因子和分区

1107-3756

1791-244X

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration, secondary bone hyperplasia, inadequate extracellular matrix synthesis and degeneration of articular cartilage. Mesenchymal stem cells (MSCs) can self-renew and undergo multidirectional differentiation; they can differentiate into chondrocytes. Aging MSCs have a weakened ability to differentiate, and release various pro-inflammatory cytokines, which may contribute to OA progression; the other mechanism contributing to OA is epigenetic regulation (for instance, DNA methylation, histone modification and regulation of non-coding RNA). Owing to the self-renewal and differentiation ability of MSCs, various MSC-based exogenous cell therapies have been developed to treat OA. The efficacy of MSC-based therapy is mainly attributed to cytokines, growth factors and the paracrine effect of exosomes. Recently, extensive studies have been conducted on MSC-derived exosomes. Exosomes from MSCs can deliver a variety of DNA, RNA, proteins and lipids, thereby facilitating MSC migration and cartilage repair. Therefore, MSC-derived exosomes are considered a promising therapy for OA. The present review summarized the association between MSC aging and OA in terms of genetics and epigenetics, and characteristics of MSC-derived exosomes, and the mechanism to alleviate OA cartilage damage.

epigenetics exosomes genetics mesenchymal stem cells osteoarthritis single-cell sequencing

SCI

英语

其他

CLINICAL MEDICINE

2-s2.0-85176762892

Scopus

1.Hand and Foot Surgery Department,Shenzhen Second People's Hospital,The First Hospital Affiliated to Shenzhen University,Guangdong,Shenzhen,518000,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Guangdong,Shenzhen,518055,China

Tan，Dunyong,Huang，Zeqi,Zhao，Zhe,et al. Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)[J]. International Journal of Molecular Medicine,2024,53(1).

Tan，Dunyong.,Huang，Zeqi.,Zhao，Zhe.,Chen，Xiaoqiang.,Liu，Jianquan.,...&Li，Wencui.(2024).Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review).International Journal of Molecular Medicine,53(1).

Tan，Dunyong,et al."Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)".International Journal of Molecular Medicine 53.1(2024).