Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion

Li，Penghui1,2,3; Li，Qingcun2; Lai，Yujian1,2; Yang，Shuping1,2; Yu，Sujuan2; Liu，Rui1,2; Jiang，Guibin1,2; Liu，Jingfu1,3,4

2023-12-15

10.1016/j.isci.2023.108454

iScience   影响因子和分区

2589-0042

Understanding the pathways of human exposure to micro(nano)plastics (MNPs) is crucial for assessing their health impacts. Intravenous infusion can induce MNPs direct entry into the human blood, posing serious risks on human health, but remains unclear. Herein, we developed comprehensive analytical methods to detect polyvinyl chloride (PVC) MNPs down to 20 nm, and found about 0.52 μg equal to 10–10 particles of PVC-MNPs released from intravenous infusion products (IVIPs) during each intravenous infusion of 250 mL injection. The released amounts of MNPs from IVIPs were dependent on the plastic materials, and the injection volume and composition. These findings indicated that the released MNPs should be directly introduced into the human blood circulatory system, causing serious impacts on human health. Our study reveals a previously ignored but important pathway of human exposure to MNPs, and calls for further research on the potential risks of these MNPs on human health.

Environmental science Health sciences Pollution

SCI

英语

通讯

WOS:001125667100001

2-s2.0-85177814093

Scopus

1.School of Environment,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,310024,China
2.State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing,100085,China
3.School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,Institute of Environment and Health,Jianghan University,Wuhan,430056,China

Li，Penghui,Li，Qingcun,Lai，Yujian,et al. Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion[J]. iScience,2023,26(12).

Li，Penghui.,Li，Qingcun.,Lai，Yujian.,Yang，Shuping.,Yu，Sujuan.,...&Liu，Jingfu.(2023).Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion.iScience,26(12).

Li，Penghui,et al."Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion".iScience 26.12(2023).