Architecturally designed sequential-release hydrogels

Zhang，Dan1; Li，Zimu1,3; Yang，Li1; Ma，Hualin2; Chen，Hongzhong1; Zeng，Xiaowei1

2023-12-01

10.1016/j.biomaterials.2023.122388

Biomaterials   影响因子和分区

0142-9612

1878-5905

Drug synergy has made significant strides in clinical applications in recent decades. However, achieving a platform that enables “single administration, multi-stage release” by emulating the natural physiological processes of the human body poses a formidable challenge in the field of molecular pharmaceutics. Hydrogels, as the novel generation of drug delivery systems, have gained widespread utilization in drug platforms owing to their exceptional biocompatibility and modifiability. Sequential drug delivery hydrogels (SDDHs), which amalgamate the advantages of hydrogel and sequential release platforms, offer a promising solution for effectively navigating the intricate human environment and accomplishing drug sequential release. Inspired by architectural design, this review establishes connections between three pivotal factors in SDDHs construction, namely mechanisms, carrier spatial structure, and stimuli-responsiveness, and three aspects of architectural design, specifically building materials, house structures, and intelligent interactive furniture, aiming at providing insights into recent developments in SDDHs. Furthermore, the dual-drug collocation and cutting-edge hydrogel preparation technologies as well as the prevailing challenges in the field were elucidated.

Architectural design Disease treatment Hydrogels Mechanisms Sequential drug delivery

SCI

英语

其他

WOS:001117086400001

MATERIALS SCIENCE

2-s2.0-85177060291

Scopus

1.School of Pharmaceutical Sciences (Shenzhen),Shenzhen Campus of Sun Yat-sen University,Shenzhen,518107,China
2.Department of Nephrology,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
3.School of Chemistry,Chemical Engineering and Biotechnology,Nanyang Technological University,21 Nanyang Link, Singapore,637371,Singapore

Zhang，Dan,Li，Zimu,Yang，Li,et al. Architecturally designed sequential-release hydrogels[J]. Biomaterials,2023,303.

Zhang，Dan,Li，Zimu,Yang，Li,Ma，Hualin,Chen，Hongzhong,&Zeng，Xiaowei.(2023).Architecturally designed sequential-release hydrogels.Biomaterials,303.

Zhang，Dan,et al."Architecturally designed sequential-release hydrogels".Biomaterials 303(2023).