OCT-based Measurement of Cerebral Blood Vessel Structure, Blood Flow Velocity, and Blood Transit Time

Yijia Zhou; Junxiong Zhou; Jianbo Tang

10.1109/PGC60057.2023.10344125

2023

Conference on Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII

1605-7422

979-8-3503-1838-8

2023 Photonics Global Conference (PGC)

12830

42-47

21-23 Aug. 2023

Stockholm, Sweden

1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA

SPIE-INT SOC OPTICAL ENGINEERING

Accurate measurement of the microcirculation dynamics, including the blood vessel 3D structure, blood flow velocity and the blood flow transit time can not only improve our understanding of the pathology of microcirculation dysfunction-related disease, but also provide important parameters for disease diagnosis, prevention, and early treatment. In this work, we introduce a comprehensive optical coherence tomography (OCT)-based functional imaging technology for the 3D measurement of the micro vessel networks' structure, blood flow velocity, and the blood flow transit time. The M-mode data acquisition (repeated A-scans) was employed in this technique. For blood vessel 3D structure imaging, we developed a first order field autocorrelation function (g1)-based adaptive analysis method to suppress the blood vessel tail artifacts and enhance the blood flow in small vessels. For blood flow velocity 3D imaging, we developed a set of quantitative dynamic analysis methods to measure both the axial and total blood flow velocity of the complex vessel network. We further developed a graphing method to obtain the 3D topological parameters of the 3D vessel network, including the vessel skeleton, branching, vessel diameter, and the blood flow speed at each location. With those information, we are able to, to the best of our knowledge, obtain the 3D blood transit time in the complex vessel network for the first of time. The proposed technique has the advantage of obtaining these three important blood flow biomarkers from a single data acquisition, which greatly simplifies the experiment procedure. The proposed OCT approach has a wide application in the field of microcirculation dysfunction-related disease studies.

optical coherence tomography microcirculation dynamics blood flow transit time blood flow velocity dynamic light scattering

第一

英语

EI ; CPCI-S

Shenzhen Science and technology Innovation Committee[20210316161406001] ; Guangdong Science and Technology Department[2022A1515011984]

Engineering ; Neurosciences & Neurology ; Optics

Engineering, Biomedical ; Neurosciences ; Optics

WOS:001239916000029

20240315384181

Blood ; Blood vessels ; Complex networks ; Data acquisition ; Diagnosis ; Flow velocity ; Light scattering ; Microcirculation

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Fluid Flow:631 ; Computer Systems and Equipment:722 ; Data Processing and Image Processing:723.2 ; Light/Optics:741.1 ; Optical Devices and Systems:741.3 ; Mechanical Variables Measurements:943.2

IEEE

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

Yijia Zhou,Junxiong Zhou,Jianbo Tang. OCT-based Measurement of Cerebral Blood Vessel Structure, Blood Flow Velocity, and Blood Transit Time[C]. 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA:SPIE-INT SOC OPTICAL ENGINEERING,2023:42-47.