南方科技大学知识苑(SUSTech KC): MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells

题名	MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells
作者	Liu, Xiangrong 1; Bai, Wenqi 2; Li, Jianrong 1; Ma, Jinfeng 1; Liu, Yan 3; Wang, Zhixiang 3; Hu, Linjie 3; Li, Zheng 3; Papukashvili, Dimitri4 ; Rcheulishvili, Nino4 ; Wang, Fusheng 2; Lu, Xiaoqing 1
通讯作者	Wang, Fusheng; Lu, Xiaoqing
发表日期	2023-12-01
DOI	10.1155/2023/6282654
发表期刊	BREAST JOURNAL 影响因子和分区
ISSN	1075-122X
EISSN	1524-4741
卷号	2023
摘要	Breast cancer is considered the most prevalent malignancy due to its high incidence rate, recurrence, and metastasis in women that makes it one of the deadliest cancers. The current study aimed to predict the genes associated with the recurrence and metastasis of breast cancer and to validate their effect on MDA-MB-231 cells. Through the bioinformatics analysis, the transcription factor 7 cofactor (MLLT11) as the target gene was obtained. MLLT11-specific siRNA was synthesized and transfected into MDA-MB-231 cells. The results demonstrated that the siRNA significantly reduced the MLLT11 mRNA levels. Moreover, cell migration and invasion, as well as the protein levels of phosphatidylinositol 3-kinase (PI3K), AKT, matrix metalloproteinase (MMP) 2, and MMP9, were significantly lower in the groups treated with siRNA while the apoptosis was augmented. Collectively, MLLT11 siRNA elicited ameliorative properties on breast cancer cells, possibly via the inhibition of the PI3K/AKT signaling pathway.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Shanxi Province Key and Plan Project[201903D321162] ; Shanxi Special Project of Guiding the Transformation of Scientific and Technological Achievements[201704D131031] ; null[82002820]
WOS研究方向	Oncology ; Obstetrics & Gynecology
WOS类目	Oncology ; Obstetrics & Gynecology
WOS记录号	WOS:001118637500001
出版者	WILEY-HINDAWI
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/638879
专题	南方科技大学
作者单位	1.Shanxi Med Univ, Shanxi Prov Canc Hosp, Chinese Acad Med Sci, Shanxi Hosp,Canc Hosp, Taiyuan 030001, Peoples R China 2.Shanxi Med Univ, Breast Surg, Hosp 2, Taiyuan 030001, Peoples R China 3.Shanxi Med Univ, Taiyuan 030006, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiangrong,Bai, Wenqi,Li, Jianrong,et al. MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells[J]. BREAST JOURNAL,2023,2023.
APA	Liu, Xiangrong.,Bai, Wenqi.,Li, Jianrong.,Ma, Jinfeng.,Liu, Yan.,...&Lu, Xiaoqing.(2023).MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells.BREAST JOURNAL,2023.
MLA	Liu, Xiangrong,et al."MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells".BREAST JOURNAL 2023(2023).