Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis

Liao, Zhidong1,2,3; Umar, Muhammad2,3; Huang, Xingyun2,3; Qin, Ling4,5; Xiao, Guozhi6; Chen, Yan1; Tong, Liping2; Chen, Di2,3

2023-11-01

10.1111/cpr.13569

CELL PROLIFERATION   影响因子和分区

0960-7722

1365-2184

["This study aims to determine the molecular mechanisms and analgesic effects of transient receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid arthritis (RA). We summarize and analyse current studies regarding the biological functions and mechanisms of TRPV1 in arthritis. We search and analyse the related literature in Google Scholar, Web of Science and PubMed databases from inception to September 2023 through the multi-combination of keywords like 'TRPV1', 'ion channel', 'osteoarthritis', 'rheumatoid arthritis' and 'pain'. TRPV1 plays a crucial role in regulating downstream gene expression and maintaining cellular function and homeostasis, especially in chondrocytes, synovial fibroblasts, macrophages and osteoclasts. In addition, TRPV1 is located in sensory nerve endings and plays an important role in nerve sensitization, defunctionalization or central sensitization. TRPV1 is a non-selective cation channel protein. Extensive evidence in recent years has established the significant involvement of TRPV1 in the development of arthritis pain and inflammation, positioning it as a promising therapeutic target for arthritis. TRPV1 likely represents a feasible therapeutic target for the treatment of OA and RA.","TRPV1, a member of the TRP family, is widely expressed in primary sensory neurons and various cells and participates in pain signal transduction of thermal, mechanical and chemical stimulation. Recently, functional changes in TRPV1 channels have been considered as risk factors for OA and RA. Abnormal expression and function of TRPV1 channels are associated with chondrocyte ferroptosis, synovial inflammatory response, macrophage polarization and bone homeostasis. In addition, TRPV1 channels play important roles in neural sensitization, defunctionalization or central sensitization and are involved in the occurrence of pain in OA and RA. Based on clinical and preclinical evidence, TRPV1-targeting drugs and regulation of its expression exhibit prominent curative effects in OA and RA. TRPV1 may be a novel potential therapeutic target for OA and RA treatment.image"]

SCI

英语

其他

Cell Biology

Cell Biology

WOS:001118326300001

WILEY

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Guangxi Med Univ, Collaborat Innovat Ctr Regenerat Med & Med BioReso, Nanning 530021, Guangxi, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen 518005, Peoples R China
3.Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen 518055, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol & Innovat Orthopaed Bio, Musculoskeletal Res Lab, Hong Kong, Peoples R China
5.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Drug Translat Res Lab, Hong Kong, Peoples R China
6.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China

Liao, Zhidong,Umar, Muhammad,Huang, Xingyun,et al. Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis[J]. CELL PROLIFERATION,2023.

Liao, Zhidong.,Umar, Muhammad.,Huang, Xingyun.,Qin, Ling.,Xiao, Guozhi.,...&Chen, Di.(2023).Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis.CELL PROLIFERATION.

Liao, Zhidong,et al."Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis".CELL PROLIFERATION (2023).