An Anisotropic Hydrogel Based on Mussel-Inspired Conductive Ferrofluid Composed of Electromagnetic Nanohybrids

Liu，Kezhi1; Han，Lu1; Tang，Pengfei1; Yang，Kaiming1; Gan，Donglin1; Wang，Xiao1; Wang，Kefeng2; Ren，Fuzeng3; Fang，Liming4; Xu，Yonggang1; Lu，Zhifeng1; Lu，Xiong1

2019-12-11

10.1021/acs.nanolett.9b00363

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

Anisotropic hydrogels with a hierarchical structure can mimic biological tissues, such as neurons or muscles that show directional functions, which are important factors for signal transduction and cell guidance. Here, we report a mussel-inspired approach to fabricate an anisotropic hydrogel based on a conductive ferrofluid. First, polydopamine (PDA) was used to mediate the formation of PDA-chelated carbon nanotube-FeO (PFeCNT) nanohybrids and also used as a dispersion medium to stabilize the nanohybrids to form a conductive ferrofluid. The ferrofluid can respond to an orientated magnetic field and be programed to form aligned structures, which were then frozen in a hydrogel network formed via in situ free-radical polymerization and gelation. The resulted hydrogel shows directional conductive and mechanical properties, mimicking an oriented biological tissue. Under external electrical stimulation, the orientated PFeCNT nanohybrids can be sensed by the myoblasts cultured on the hydrogel, resulting in the oriented growth of cells. In summary, the mussel-inspired anisotropic hydrogel with its aligned structural complexity and anisotropic properties together with the cell affinity and tissue adhesiveness is a potent multifunctional biomaterial for mimicking oriented tissues to guide cell proliferation and tissue regeneration.

Anisotropic hydrogels carbon nanotube conductive hydrogels ferrofluid magnetic nanoparticles mussel-inspired adhesive hydrogels

SCI ; EI

英语

NI期刊

其他

China Postdoctoral Science Foundation[2017M622997] ; National Basic Research Program of China (973 Program)[2016YFB0700802] ; [2019B010941002] ; National Natural Science Foundation of China[81671824] ; Fundamental Research Funds for the Central Universities[2682019JQ03]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000502687500001

American Chemical Society

20194607666882

Adhesives ; Anisotropy ; Biomechanics ; Carbon nanotubes ; Cell proliferation ; Cells ; Cytology ; Free radical polymerization ; Free radicals ; Gelation ; Histology ; Iron oxides ; Magnetic fluids ; Magnetite ; Molluscs ; Nanomagnetics ; Nanoparticles ; Signal transduction ; Tissue ; Tissue regeneration

Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Magnetic Materials:708.4 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Polymerization:815.2 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Solid State Physics:933

MATERIALS SCIENCE

2-s2.0-85074649317

Scopus

1.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu, Sichuan,610031,China
2.National Engineering Research Center for Biomaterials,Research Center for Materials Genome Engineering,Chengdu, Sichuan,610064,China
3.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
4.Department of Polymer Science and Engineering,School of Materials Science and Engineering,South China University of Technology,Guangzhou,510641,China

Liu，Kezhi,Han，Lu,Tang，Pengfei,et al. An Anisotropic Hydrogel Based on Mussel-Inspired Conductive Ferrofluid Composed of Electromagnetic Nanohybrids[J]. NANO LETTERS,2019,19(12):8343-8356.

Liu，Kezhi.,Han，Lu.,Tang，Pengfei.,Yang，Kaiming.,Gan，Donglin.,...&Lu，Xiong.(2019).An Anisotropic Hydrogel Based on Mussel-Inspired Conductive Ferrofluid Composed of Electromagnetic Nanohybrids.NANO LETTERS,19(12),8343-8356.

Liu，Kezhi,et al."An Anisotropic Hydrogel Based on Mussel-Inspired Conductive Ferrofluid Composed of Electromagnetic Nanohybrids".NANO LETTERS 19.12(2019):8343-8356.