南方科技大学知识苑(SUSTech KC): Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study

题名	Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study
作者	Keyong Huang 1,2; Jiajing Jia 1,2; Fengchao Liang3 ; Lianxin Li 1,2; Xiaoge Niu 1,2,4; Xueli Yang 5; Shufeng Chen 1,2; Jie Cao 1,2; Chong Shen 6,7; Xiaoqing Liu 8; Ling Yu 9; Fanghong Lu 10; Xianping Wu 11; LLiancheng Zhao 1,2; Ying Li 1,2; Dongsheng Hu 1,12,13; Jianfeng Huang 1,2; Yang Liu 14; Dongfeng Gu2,15 ; Fangchao Liu 1,2; Xiangfeng Lu 1,2
通讯作者	Fangchao Liu; Xiangfeng Lu
共同第一作者	Jiajing Jia
发表日期	2023-11-29
DOI	10.1161/STROKEAHA.123.043812
发表期刊	Stroke 影响因子和分区
ISSN	0039-2499
EISSN	1524-4628
卷号	55 期号:1页码:92-100
摘要	Background: Both genetic factors and environmental air pollution contribute to the risk of stroke. However, it is unknown whether the association between air pollution and stroke risk is influenced by the genetic susceptibilities of stroke and its risk factors. Methods: This prospective cohort study included 40 827 Chinese adults without stroke history. Satellite-based monthly fine particulate matter (PM) estimation at 1-km resolution was used for exposure assessment. Based on 534 identified genetic variants from genome-wide association studies in East Asians, we constructed 6 polygenic risk scores for stroke and its risk factors, including atrial fibrillation, blood pressure, type 2 diabetes, body mass index, and triglyceride. The Cox proportional hazards model was applied to evaluate the hazard ratios and 95% CIs for the associations of PM and polygenic risk score with incident stroke and the potential effect modifications. Results: Over a median follow-up of 12.06 years, 3147 incident stroke cases were documented. Compared with the lowest quartile of PM exposure, the hazard ratio (95% CI) for stroke in the highest quartile group was 2.72 (2.42-3.06). Among individuals at high genetic risk, the relative risk of stroke was 57% (1.57; 1.40-1.76) higher than those at low genetic risk. Although no statistically significant interaction was found, participants with both the highest PM and high genetic risk showed the highest risk of stroke, with ≈4× that of the lowest PM and low genetic risk group (hazard ratio, 3.55 [95% CI, 2.84-4.44]). Similar upward gradients were observed in the risk of stroke when assessing the joint effects of PM and genetic risks of blood pressure, type 2 diabetes, body mass index, atrial fibrillation, and triglyceride. Conclusions: Long-term exposure to PM was associated with a higher risk of incident stroke across different genetic susceptibilities. Our findings highlighted the great importance of comprehensive assessment of air pollution and genetic risk in the prevention of stroke.
关键词	Air Pollution Genetic Association Studies Particulate Matter Stroke
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
ESI学科分类	NEUROSCIENCE & BEHAVIOR
Scopus记录号	2-s2.0-85181040349
来源库	人工提交
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/646904
专题	南方科技大学医学院_公共卫生及应急管理学院南方科技大学医学院
作者单位	1.Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (K.H., J.J., J.L., X.N., S.C., J.C., L.Z., Y. Li, J.H., D.G., F. Liu, X. Lu). 2.Key Laboratory of Cardiovascular Epidemiology (K.H., J.J., J.L., S.C., J.C., L.Z., Y. Li, J.H., D.G., F. Liu, X. Lu), Chinese Academy of Medical Sciences, Beijing, China. 3.School of Public Health and Emergency Management (F. Liang), Southern University of Science and Technology, Shenzhen, China. 4.Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, China (X.N.). 5.Tianjin Key Laboratory of Environment, Nutrition and Public Health, Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, China (X.Y.). 6.Research Units of Cohort Study on Cardiovascular Diseases and Cancers (C.S.), Chinese Academy of Medical Sciences, Beijing, China. 7.Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (C.S.). 8.Division of Epidemiology, Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou, China (X. Liu). 9.Department of Cardiology, Fujian Provincial People's Hospital, Fuzhou, China (L.Y.). 10.Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, China (F. Lu). 11.Sichuan Center for Disease Control and Prevention, Chengdu, China (X.W.). 12.Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, China (D.H.). 13.Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, China (D.H.). 14.Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA (Y. Liu). 15.School of Medicine (D.G), Southern University of Science and Technology, Shenzhen, China.
推荐引用方式 GB/T 7714	Keyong Huang,Jiajing Jia,Fengchao Liang,et al. Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study[J]. Stroke,2023,55(1):92-100.
APA	Keyong Huang.,Jiajing Jia.,Fengchao Liang.,Lianxin Li.,Xiaoge Niu.,...&Xiangfeng Lu.(2023).Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study.Stroke,55(1),92-100.
MLA	Keyong Huang,et al."Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study".Stroke 55.1(2023):92-100.