Encoded Magnetization for Programmable Soft Miniature Machines by Covalent Assembly of Modularly Coupled Microgels

Tanyong Wei; Ruizhou Zhao; Lijun Fang; Zongze Li; Ming Yang; Zhen Zhan; U. Kei Cheang; Chengzhi Hu

2023-12-29

Advanced Functional Materials   影响因子和分区

1616-301X

1616-3028

The bottom-up assembly of premagnetized microgels offers remarkable flexibility in programmability, material selection, and complexity for fabricating programmable magnetic soft machines with discrete 3D magnetization profiles. However, the current microgel bonding encounters challenges due to the utilization of adhesives for attachment, biocompatibility for in vivo applications, and the need for elevated temperature for self-healing materials. Here, an approach is presented that leverages N-hydroxysuccinimide ester-activated sodium alginate (SA-NHS) and chitosan (CS) to form modular gels for on-demand assembly through covalent bonding, yielding a tough and durable interface. Photolithography-based patterning and magnetic maneuverability are imparted by introducing poly(ethylene glycol) diacrylate and ferromagnetic particles into SA-NHS or CS, resulting in the creation of modularized magnetic or nonmagnetic microgels. Different magnetization profiles of the modular microgel can be achieved by magnetizing the ferromagnetic particles inside the microgel. To prove the versatility of the proposed method, several programmable magnetic soft machines are developed for various application scenarios, including heterogeneous cell-laden hydrogel assemblies, multisegmented magnetic soft swimmers, programmable magnetic switches for electric circuits, and magnetically triggered release from drug-encapsulated magnetic capsules. This proposed approach holds great potential to engineer highly intricate and hierarchical architectures, enhancing the functionality, versatility, and adaptability of programmable soft machines.

coupled modular gels covalent adhesion magnetic soft machines microassembly programmable machines

SCI ; EI

英语

第一 ; 通讯

20240115313528

Adhesives ; Biocompatibility ; Drug delivery ; Electric switches ; Ferromagnetic materials ; Ferromagnetism ; Hydrogels ; Magnetization ; Polyethylene glycols ; Sodium alginate

Immunology:461.9.1 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Magnetic Materials:708.4 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1

MATERIALS SCIENCE

2-s2.0-85180894468

人工提交

南方科技大学

Tanyong Wei,Ruizhou Zhao,Lijun Fang,et al. Encoded Magnetization for Programmable Soft Miniature Machines by Covalent Assembly of Modularly Coupled Microgels[J]. Advanced Functional Materials,2023,34(16).

Tanyong Wei.,Ruizhou Zhao.,Lijun Fang.,Zongze Li.,Ming Yang.,...&Chengzhi Hu.(2023).Encoded Magnetization for Programmable Soft Miniature Machines by Covalent Assembly of Modularly Coupled Microgels.Advanced Functional Materials,34(16).

Tanyong Wei,et al."Encoded Magnetization for Programmable Soft Miniature Machines by Covalent Assembly of Modularly Coupled Microgels".Advanced Functional Materials 34.16(2023).