3D Printed Implantable Hydrogel Bioelectronics for Electrophysiological Monitoring and Electrical Modulation

Fucheng,Wang1,2; Yu,Xue1; Xingmei,Chen1; Pei,Zhang1; Liangjie,Shan1; Qingfang,Duan1; Junfei,Xing1; Yang,Lan3; Baoyang,Lu2; Ji,Liu1,4,5,6

2023-12-21

10.1002/adfm.202314471

Advanced Functional Materials   影响因子和分区

1616-301X

1616-3028

Electronic devices based on conducting polymer hydrogels have emerged as one of the most promising implantable bioelectronics for electrophysiological monitoring and diagnosis of a wide spectrum of diseases, in light of their distinct conductivity and biocompatibility. However, most conducting polymer hydrogels-based bioelectronics are routinely fabricated through conventional techniques, which are challenged by its intrinsic poor processability of conducting polymers, as well as the essentially fragile biointerface, thus hampering their rapid innovation and application in advanced implantable bioelectronics. Here, 3D printable hydrogels based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is reported, featuring superior 3D printability for direct ink writing (DIW), tissue-like mechanical compliance (Young's modulus of 650 kPa), instant and tough bioadhesion (interfacial toughness of 200 J m and shear strength of 120 kPa), highly-tunable electrical properties, as well as long-term in vitro and in vivo structural and electrochemical robustness. Electro-physiological studies rat heart models with normal or arrhythmic conditions highlight the capabilities of establishing conformal biointerface with the dynamic organs, allowing for long-term and high-precision spatiotemporary epicardial electrophysiological monitoring, as well as electrical modulation of acute myocardial infarction (MI) model. These advances provide a promising strategy to improve the tissue-electronics interfacing, and could serve as the basis for the next generation bioelectronics toward healthcare monitoring, diagnosis and medical therapies.

3D Printing biointerface electrical simulation electrophysiological recording hydrogel bioelectronics

SCI ; EI

英语

NI论文

第一 ; 通讯

WOS:001128495700001

Wiley

20235215265701

3D printing ; Biocompatibility ; Diagnosis ; Elastic moduli ; Electrophysiology ; Hydrogels ; Physiological models ; Tissue

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Conducting Materials:708.2 ; Printing Equipment:745.1.1 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Polymeric Materials:815.1 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85180167236

人工提交

1.Department of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen 518055, China
2.Jiangxi Key Lab of Flexible Electronics Flexible Electronics Innovation Institute Jiangxi Science and Technology Normal University Nanchang, Jiangxi 330013, China
3.Department of Chemical Engineering University College London London WC1E 7JE, U.K.
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen 518055, China
5.Shenzhen Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems Southern University of Science and Technology Shenzhen 518055, China
6.Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology Shenzhen 518055, China Adv. Funct. Mater. 2023, 2314471 © 2023 Wiley-VCH GmbH2314471 (1 of 11)

Fucheng,Wang,Yu,Xue,Xingmei,Chen,et al. 3D Printed Implantable Hydrogel Bioelectronics for Electrophysiological Monitoring and Electrical Modulation[J]. Advanced Functional Materials,2023,34(21):2314471 (1 of 11).

Fucheng,Wang.,Yu,Xue.,Xingmei,Chen.,Pei,Zhang.,Liangjie,Shan.,...&Ji,Liu.(2023).3D Printed Implantable Hydrogel Bioelectronics for Electrophysiological Monitoring and Electrical Modulation.Advanced Functional Materials,34(21),2314471 (1 of 11).

Fucheng,Wang,et al."3D Printed Implantable Hydrogel Bioelectronics for Electrophysiological Monitoring and Electrical Modulation".Advanced Functional Materials 34.21(2023):2314471 (1 of 11).