Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy

Zhang，Zhao1; Wei，Zixiang1; Guo，Jintong1; Lyu，Jinxiao1; Wang，Bingzhe2; Wang，Gang2; Wang，Chunfei1; Zhou，Liqiang1,3; Yuan，Zhen1,3; Xing，Guichuan2; Wu，Changfeng4; Zhang，Xuanjun1,3

2024-12-01

10.1038/s41467-023-43890-z

Nature Communications   影响因子和分区

2041-1723

Practical photodynamic therapy calls for high-performance, less O-dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O-dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region. Reactive oxygen species generation of metallopolymer Ir-P1, where the iridium atom is covalently coupled to the polymer backbone, is over 80 times higher than that of its mother polymer without iridium under 680 nm irradiation. This strategy also works effectively when the iridium atom is directly included (Ir-P2) in the polymer backbones, exhibiting wide generality. The metallopolymer nanoparticles exhibiting efficient O generation are conjugated with integrin αvβ3 binding cRGD to achieve targeted photodynamic therapy.

SCI

英语

其他

2-s2.0-85181241254

Scopus

1.Cancer Centre and Centre of Reproduction,Development and Aging,Faculty of Health Sciences,University of Macau,999078,Macao
2.Institute of Applied Physics and Materials Engineering,University of Macau,999078,Macao
3.MOE Frontiers Science Centre for Precision Oncology,University of Macau,999078,Macao
4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Zhang，Zhao,Wei，Zixiang,Guo，Jintong,et al. Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy[J]. Nature Communications,2024,15(1).

Zhang，Zhao.,Wei，Zixiang.,Guo，Jintong.,Lyu，Jinxiao.,Wang，Bingzhe.,...&Zhang，Xuanjun.(2024).Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy.Nature Communications,15(1).

Zhang，Zhao,et al."Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy".Nature Communications 15.1(2024).