Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A

Wu，Jiancong1; Huang，Xiaobi1; Li，Xiaofang2; Zhou，Honglian1; Chen，Xiaorao1; Chen，Yongyang1; Guo，Yudong1; Huang，Jian3; Huang，Hanqing3; Huang，Zhong1; Chen，Guoan4; Yang，Zhixiong1; Zhang，Jian4; Su，Wenmei1,5

2024-12-01

10.1007/s12672-023-00855-4

Discover Oncology   影响因子和分区

2730-6011

Long non-coding RNAs play critical roles in the development of lung cancer by functioning as tumor suppressors or oncogenes. Changes in the expression of LINC01279 have been associated with cell differentiation and human diseases. However, the mechanism underlying LINC01279 activity in tumorigenesis is not clear. Here, we analyzed the function of LINC01279 in lung adenocarcinoma using clinical samples, xenografts, and non-small-cell lung cancer cell lines. We found that LINC01279 is highly expressed in lung adenocarcinoma and may be considered as a predictive factor for this cancer. Knockdown of LINC01279 prevents tumor growth in xenografts and in cancer cell lines by activating autophagy and apoptosis. Molecularly, we revealed that LINC01279 regulates the expression of focal adhesion kinase and extracellular-regulated kinase signaling. In addition, it complexes with and stabilizes the transcriptional co-repressor SIN3A protein. Suppression of focal adhesion kinase and SIN3A also induces apoptosis and prevents tumor progression, suggesting that they may at least in part mediate the oncogenic activity of LINC01279. These results identify LINC01279 as a possible oncogene that plays an important role in the development of lung cancer. Our findings provide insights into the mechanism underlying LINC01279-mediated oncogenesis of lung adenocarcinoma. They may help to discover potential therapeutic targets for cancer diagnosis and prognosis.

Apoptosis Autophagy FAK LINC01279 lncRNA Lung adenocarcinoma SIN3A

SCI

英语

其他

2-s2.0-85181205123

Scopus

1.Department of Pulmonary Oncology,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
2.Center for Pathological Diagnosis and Research,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
3.Department of Thoracic Surgery,Maoming People’s Hospital,Maoming,China
4.School of Medicine,Southern University of Science and Technology,Shenzhen,China
5.Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China

Wu，Jiancong,Huang，Xiaobi,Li，Xiaofang,et al. Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A[J]. Discover Oncology,2024,15(1).

Wu，Jiancong.,Huang，Xiaobi.,Li，Xiaofang.,Zhou，Honglian.,Chen，Xiaorao.,...&Su，Wenmei.(2024).Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A.Discover Oncology,15(1).

Wu，Jiancong,et al."Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A".Discover Oncology 15.1(2024).