南方科技大学知识苑(SUSTech KC): DHX33 mediates p53 to regulate mevalonate pathway gene transcription in human cancers

题名	DHX33 mediates p53 to regulate mevalonate pathway gene transcription in human cancers
作者	Nie，Guangli 1; Chen，Shiyun1,2 ; Song，Qingzhi 3; Zou，Dongxu 1; Li，Maggie 4; Tang，Xiyu 1; Deng，Yuanlian 1; Huang，Bizhou 1; Yang，Mengxia 1; Lv，Guoqing 4; Zhang，Yandong1,2
通讯作者	Zhang，Yandong
发表日期	2024-03-01
DOI	10.1016/j.bbagen.2023.130547
发表期刊	Biochimica et Biophysica Acta - General Subjects 影响因子和分区
ISSN	0304-4165
EISSN	1872-8006
卷号	1868 期号:3
摘要	Tumor suppressor p53 is frequently null or mutated in human cancers. Here in this study, DHX33 protein was found to be induced in p53 null cells in vitro, and in p53 mutant lung tumorigenesis in vivo. Cholesterol metabolism through mevalonate pathway is pivotal for cell proliferation and is frequently altered in human cancers. Mice carrying mutant p53 and Kras alleles showed upregulation of mevalonate pathway gene expression. However upon DHX33 loss, their upregulation was significantly debilitated. Additionally, in many human cancer cells, DHX33 knockdown caused inhibition of mavelonate pathway gene transcription. We propose DHX33 locates downstream of mutant p53 and Ras to regulate mevalonate pathway gene transcription and thereby supports cancer development in vivo.
关键词	DHX33 Mevalonate pathway p53 RAS RNA helicase
相关链接	[Scopus记录]
语种	英语
学校署名	通讯
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85181141503
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/669621
专题	南方科技大学
作者单位	1.Shenzhen KeYe Life Technologies Co.,Ltd,Shenzhen,Guangdong,518000,China 2.Southern University of Science and Technology,Shenzhen,China 3.Department of Gastrointestinal Surgery,Peking University Shenzhen Hospital,China 4.Shenzhen College of International Education,Shenzhen,China
通讯作者单位	南方科技大学
推荐引用方式 GB/T 7714	Nie，Guangli,Chen，Shiyun,Song，Qingzhi,et al. DHX33 mediates p53 to regulate mevalonate pathway gene transcription in human cancers[J]. Biochimica et Biophysica Acta - General Subjects,2024,1868(3).
APA	Nie，Guangli.,Chen，Shiyun.,Song，Qingzhi.,Zou，Dongxu.,Li，Maggie.,...&Zhang，Yandong.(2024).DHX33 mediates p53 to regulate mevalonate pathway gene transcription in human cancers.Biochimica et Biophysica Acta - General Subjects,1868(3).
MLA	Nie，Guangli,et al."DHX33 mediates p53 to regulate mevalonate pathway gene transcription in human cancers".Biochimica et Biophysica Acta - General Subjects 1868.3(2024).