Lipid metabolism analysis in esophageal cancer and associated drug discovery

Jiao，Ruidi1,2,3; Jiang，Wei2; Xu，Kunpeng2; Luo，Qian1,4; Wang，Luhua2,3; Zhao，Chao1,4,5

2024

10.1016/j.jpha.2023.08.019

Journal of Pharmaceutical Analysis   影响因子和分区

2095-1779

Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis. It is still being explored in depth due to its complex molecular mechanisms of occurrence and development. Lipids play a crucial role in cells by participating in energy supply, biofilm formation, and signal transduction processes, and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tumors. More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning, progress, and treatment resistance. The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism. Therefore, we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer, and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer, as well as its significance in exploring potential therapeutic targets and biomarkers.

Esophageal cancer Lipid metabolism New therapeutic targets Progression Treatment resistance

SCI

英语

其他

2-s2.0-85181145208

Scopus

1.Bionic Sensing and Intelligence Center,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518000,China
2.Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,Guangdong,518116,China
3.School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518000,China
4.University of Chinese Academy of Sciences,Beijing,100049,China
5.Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518000,China

Jiao，Ruidi,Jiang，Wei,Xu，Kunpeng,et al. Lipid metabolism analysis in esophageal cancer and associated drug discovery[J]. Journal of Pharmaceutical Analysis,2024.

Jiao，Ruidi,Jiang，Wei,Xu，Kunpeng,Luo，Qian,Wang，Luhua,&Zhao，Chao.(2024).Lipid metabolism analysis in esophageal cancer and associated drug discovery.Journal of Pharmaceutical Analysis.

Jiao，Ruidi,et al."Lipid metabolism analysis in esophageal cancer and associated drug discovery".Journal of Pharmaceutical Analysis (2024).