Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives

Li，Tianfeng1,2; Ashrafizadeh，Milad2,3,4; Shang，Yuru5; Nuri Ertas，Yavuz6,7; Orive，Gorka8,9,10,11,12

2024

10.1016/j.drudis.2023.103851

Drug Discovery Today   影响因子和分区

1359-6446

1878-5832

Breast cancer is the most common and malignant tumor among women. Chitosan (CS)-based nanoparticles have been introduced into breast cancer therapy as a way to increase the targeted delivery of drugs and genes to the tumor site. CS nanostructures suppress tumorigenesis by enhancing both the targeted delivery of cargo (drug and gene) and its accumulation in tumor cells. The tumor cells internalize CS-based nanoparticles through endocytosis. Moreover, chitosan nanocarriers can also induce phototherapy-mediated tumor ablation. Smart and multifunctional types of CS nanoparticles, including pH-, light- and redox-responsive nanoparticles, can be used to improve the potential for breast cancer removal. In addition, the acceleration of immunotherapy by CS nanoparticles has also been achieved, and there is potential to develop CS-nanoparticle hydrogels that can be used to suppress tumorigenesis.

breast cancer Chitosan drug and gene delivery phototherapy theranostic

SCI

英语

其他

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85180558675

Scopus

1.Reproductive Medicine Center,Shenzhen Maternity & Child Healthcare Hospital,Southern Medical University,Shenzhen,Guangdong,518055,China
2.Department of General Surgery,Institute of Precision Diagnosis and Treatment of Digestive System Tumors,Carson International Cancer Center,Shenzhen University General Hospital,Shenzhen University,Shenzhen,Guangdong,518055,China
3.Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai,200032,China
4.Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan,Shandong 250000,China
5.Southern University of Science and Technology Hospital,Shenzhen,518055,China
6.ERNAM-Nanotechnology Research and Application Center,Erciyes University,Kayseri,38039,Turkey
7.Department of Biomedical Engineering,Erciyes University,Kayseri,Turkey
8.NanoBioCel Research Group,School of Pharmacy,University of the Basque Country (UPV/EHU),Vitoria-Gasteiz,Spain
9.Bioaraba,NanoBioCel Research Group,Vitoria-Gasteiz,Spain
10.Biomedical Research Networking Centre in Bioengineering,Biomaterials and Nanomedicine (CIBER-BBN),Vitoria-Gasteiz,Spain
11.BTI-Biotechnology Institute,Vitoria,Spain
12.University Institute for Regenerative Medicine and Oral Implantology (UIRMI) (UPV/EHU-Fundación Eduardo Anitua),Vitoria-Gasteiz,Spain

Li，Tianfeng,Ashrafizadeh，Milad,Shang，Yuru,et al. Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives[J]. Drug Discovery Today,2024,29(1).

Li，Tianfeng,Ashrafizadeh，Milad,Shang，Yuru,Nuri Ertas，Yavuz,&Orive，Gorka.(2024).Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives.Drug Discovery Today,29(1).

Li，Tianfeng,et al."Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives".Drug Discovery Today 29.1(2024).