Photocatalytic N-Alkylation of NH-Diaryl Sulfondiimines via Anti-Markovnikov Hydroamination with Styrenes

Wang，Cong1,2; Tao，Anjin3; Jia，Tiezheng2,4

2023-12-15

10.1021/acs.orglett.3c03608

Organic Letters   影响因子和分区

1523-7060

1523-7052

Sulfondiimines, which are isoelectronic with sulfones and sulfoximines, represent a neglected yet intriguing pharmacophore in the discovery program. Herein, we present a facile and mild photocatalytic anti-Markovnikov hydroamination of styrenes for the construction of N-alkylated sulfondiimines with primary, secondary, and tertiary alkyl substituents. A sulfondiimine-derived analogue of the marketed drug Vioxx was synthesized using this method as the key step.

SCI

英语

NI论文

通讯

CHEMISTRY

2-s2.0-85180012021

Scopus

1.School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,150001,China
2.Research Center for Chemical Biology and Omics Analysis,Department of Chemistry,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Boulevard, Guangdong,518055,China
3.Shenzhen C&C Biopharmaceutical Company,Ltd.,Shenzhen,1 Taohua Road, Guangdong,518055,China
4.State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin,94 Weijin Road,300071,China

Wang，Cong,Tao，Anjin,Jia，Tiezheng. Photocatalytic N-Alkylation of NH-Diaryl Sulfondiimines via Anti-Markovnikov Hydroamination with Styrenes[J]. Organic Letters,2023,25(49):8861-8865.

Wang，Cong,Tao，Anjin,&Jia，Tiezheng.(2023).Photocatalytic N-Alkylation of NH-Diaryl Sulfondiimines via Anti-Markovnikov Hydroamination with Styrenes.Organic Letters,25(49),8861-8865.

Wang，Cong,et al."Photocatalytic N-Alkylation of NH-Diaryl Sulfondiimines via Anti-Markovnikov Hydroamination with Styrenes".Organic Letters 25.49(2023):8861-8865.