Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice

Liu，Lin1,2,3; Fan，Haiyang1,2,3; Li，Liang2,3; Fan，Yunping1

2023-12-01

10.1186/s12931-023-02619-8

Respiratory Research   影响因子和分区

1465-9921

1465-993X

Background: Type 2 diabetes mellitus (T2DM) is widely prevalent worldwide, and respiratory tract infections (RTIs) have become the primary cause of death for T2DM patients who develop concurrent infections. Among these, Pseudomonas aeruginosa infection has been found to exhibit a high mortality rate and poor prognosis and is frequently observed in bacterial infections that are concurrent with COVID-19. Studies have suggested that acarbose can be used to treat T2DM and reduce inflammation. Our objective was to explore the effect of acarbose on P. aeruginosa RTI in T2DM individuals and elucidate its underlying mechanism. Methods: High-fat diet (HFD) induction and P. aeruginosa inhalation were used to establish a RTI model in T2DM mice. The effect and mechanism of acarbose administered by gavage on P. aeruginosa RTI were investigated in T2DM and nondiabetic mice using survival curves, pathological examination, and transcriptomics. Results: We found that P. aeruginosa RTI was more severe in T2DM mice than in nondiabetic individuals, which could be attributed to the activation of the NF-κB and TREM-1 signaling pathways. When acarbose alleviated P. aeruginosa RTI in T2DM mice, both HIF-1α and NF-κB signaling pathways were inhibited. Furthermore, inhibition of the calcium ion signaling pathway and NF-κB signaling pathway contributed to the attenuation of P. aeruginosa RTI by acarbose in nondiabetic mice. Conclusions: This study confirmed the attenuating effect of acarbose on P. aeruginosa RTIs in T2DM and nondiabetic mice and investigated its mechanism, providing novel support for its clinical application in related diseases.

Acarbose NF-κB signaling pathway P. aeruginosa Respiratory tract infection Type 2 diabetes mellitus

SCI

英语

其他

CLINICAL MEDICINE

2-s2.0-85179695151

Scopus

1.Department of Otolaryngology,The Seventh Affiliated Hospital,Sun Yat-Sen University,Shenzhen,China
2.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China
3.Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China

Liu，Lin,Fan，Haiyang,Li，Liang,et al. Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice[J]. Respiratory Research,2023,24(1).

Liu，Lin,Fan，Haiyang,Li，Liang,&Fan，Yunping.(2023).Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice.Respiratory Research,24(1).

Liu，Lin,et al."Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice".Respiratory Research 24.1(2023).