The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking

Chen，Guo Chong1,2; Nyarko Hukportie，Daniel3; Wan，Zhongxiao1; Li，Fu Rong3,4; Wu，Xian Bo4

2023-12-01

10.1093/gerona/glac228

The journals of gerontology. Series A, Biological sciences and medical sciences   影响因子和分区

1758-535X

BACKGROUND: The influence of overall air pollution on dementia risk and the potential effect modification by other risk factors remain to be clarified. METHODS: We included 459 844 UK residents who were free of dementia and had data on the exposure to particulate matter (PM)2.5, PM2.5-10, PM10, NO2, and NOx during baseline recruitment. The combined exposure to various PMs and NOx was estimated by using an air pollution score. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia were estimated by multivariable Cox models. RESULTS: During a median 11.7 years follow-up, 5 905 incident cases of all-cause dementia were identified. With the exception of PM2.5-10, all other air pollutants were separately associated with a higher risk of all-cause dementia (all p-trend < .001) with generally similar associations for dementia subtypes. An increasing air pollution score was associated with higher risks of all-cause as well as individual dementia outcomes, with adjusted HRs (95% CI) of 1.27 (1.18, 1.37) for all-cause dementia, 1.27 (1.14, 1.43) for Alzheimer's disease, and 1.35 (1.16, 1.57) for vascular dementia when comparing the highest with the lowest quartile of the score (all p-trend < .001). These associations of air pollution score with dementia and its subtypes were observed among never and former smokers but not among current smokers (all p-interaction 
< .030). CONCLUSION: Air pollution was associated with a higher risk of dementia among nonsmokers but not current smokers. Additional studies are required to confirm our findings and to explore the potential mechanisms underlying the possible effect modification by smoking status.

Air pollution Dementia Prospective study Smoking UK Biobank

SCI ; SSCI

英语

其他

CLINICAL MEDICINE

2-s2.0-85168320787

Scopus

1.Department of Nutrition and Food Hygiene,School of Public Health,Suzhou Medical College of Soochow University,Suzhou,China
2.Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,United States
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
4.Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou,China

Chen，Guo Chong,Nyarko Hukportie，Daniel,Wan，Zhongxiao,et al. The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking[J]. The journals of gerontology. Series A, Biological sciences and medical sciences,2023,78(12):2309-2317.

Chen，Guo Chong,Nyarko Hukportie，Daniel,Wan，Zhongxiao,Li，Fu Rong,&Wu，Xian Bo.(2023).The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking.The journals of gerontology. Series A, Biological sciences and medical sciences,78(12),2309-2317.

Chen，Guo Chong,et al."The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking".The journals of gerontology. Series A, Biological sciences and medical sciences 78.12(2023):2309-2317.