南方科技大学知识苑(SUSTech KC): Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models

题名	Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
作者	Zhang, Yanjun 1; Sun, Jing 1; Zheng, Jian 2; Li, Suxiang 1; Rao, Haiyue 1; Dai, Jun 3; Zhang, Zhaoyong 1; Wang, Yanqun 1; Liu, Donglan 1; Chen, Zhao 1; Ran, Wei 1; Zhu, Airu 1; Li, Fang 1; Yan, Qihong 1; Wang, Yiliang 1; Yu, Kuai 1; Zhang, Shengnan 1; Wang, Dong 1; Tang, Yanhong 1; Liu, Banghui 4; Cheng, Linling 1; Huo, Jiandong 1,5; Perlman, Stanley 2; Zhao, Jingxian 1,5; Zhao, Jincun 1,5,6,7,8
通讯作者	Huo, Jiandong; Perlman, Stanley; Zhao, Jingxian; Zhao, Jincun
发表日期	2023
DOI	10.1002/advs.202303366
发表期刊	Advanced Science 影响因子和分区
EISSN	2198-3844
卷号	11 期号:9
摘要	To combat SARS-CoV-2 variants and MERS-CoV, as well as the potential re-emergence of SARS-CoV and spillovers of sarbecoviruses, which pose a significant threat to global public health, vaccines that can confer broad-spectrum protection against betacoronaviruses (β-CoVs) are urgently needed. A mosaic ferritin nanoparticle vaccine is developed that co-displays the spike receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 Wild-type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10 µg administered at a 21-day interval induced a Th1-biased immune response in mice and elicited robust cross-reactive neutralizing antibody responses against a variety of β-CoVs, including a series of SARS-CoV-2 variants. It is also able to effectively protect against challenges of SARS-CoV, MERS-CoV, and SARS-CoV-2 variants in not only young mice but also the more vulnerable mice through induction of long-lived immunity. Together, these results suggest that this mosaic 3-RBD nanoparticle has the potential to be developed as a pan-β-CoV vaccine. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
关键词	mosaic RBD nanoparticle vaccine coronavirus
相关链接	[Scopus记录]
收录类别	EI ; SCI
语种	英语
学校署名	通讯
资助项目	Y.Z., J.S., J.Z., SL, H.R., and J.D. contributed equally to this work. This project was supported by the National Key R&D Program of China (No. 2021YFC2301700 CF), the National Natural Science Foundation of China (82001750 YZ, 82025001 JZ, 82172240 YW, 82170003 LC), the ZhongNanShan Medical Foundation of Guangdong Province (ZNSA‐2020013), the Guangdong Basic and Applied Basic Research Foundation (2022B1515020059, 2021B1515130005 JXZ, 2019B1515120068 JCZ, 2023B1515020040 YW, 2021B1212030016 JD, 2021A1111100009 JD,2022B1515020059 JS) and the Guangzhou Basic Research Program (202102010350 LC).
出版者	John Wiley and Sons Inc
EI入藏号	20235115246916
EI主题词	Diseases ; Health risks ; Mammals ; MERS ; Nanoparticles ; Vaccines
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Health Care:461.7 ; Nanotechnology:761 ; Solid State Physics:933
Scopus记录号	2-s2.0-85179942429
来源库	EV Compendex
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/673783
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou; 510300, China 2.Department of Microbiology and Immunology, University of Iowa, Iowa City; IA; 52242, United States 3.Guangzhou Customs District Technology Center, Guangzhou; 510700, China 4.State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou; 510530, China 5.Guangzhou laboratory, Bio-island, Guangzhou; 510320, China 6.Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou; 510060, China 7.Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, the Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen; 518112, China 8.Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai; 201210, China
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Zhang, Yanjun,Sun, Jing,Zheng, Jian,et al. Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models[J]. Advanced Science,2023,11(9).
APA	Zhang, Yanjun.,Sun, Jing.,Zheng, Jian.,Li, Suxiang.,Rao, Haiyue.,...&Zhao, Jincun.(2023).Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models.Advanced Science,11(9).
MLA	Zhang, Yanjun,et al."Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models".Advanced Science 11.9(2023).