南方科技大学知识苑(SUSTech KC): Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

题名	Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47
作者	Chunliu,Huang 1,2; Xuefei,Wang3 ; Yingzhao,Wang 2; Yongyi,Feng 4; Xiumei,Wang 4; Shan,Chen 3; Peidong,Yan 3; Jing,Liao 5; Qi,Zhang 3; Chengzhou,Mao 6; Yang,Li 7 ; Lixiang,Wang 4; Xinyu,Wang 4; Wei,Yi 8; Weibin,Cai 9,10; Shoudeng,Chen 1; Ni,Hong3 ; Weiling,He 2,11; Jun,Chen 4,9,12,13; Wenfei,Jin3,14
通讯作者	Ni,Hong; Weiling,He; Jun,Chen; Wenfei,Jin
共同第一作者	Chunliu,Huang; Xuefei,Wang; Yingzhao,Wang
发表日期	2024-01-10
DOI	10.1038/s43018-023-00691-z
发表期刊	Nature Cancer 影响因子和分区
ISSN	2662-1347
EISSN	2662-1347
摘要	Immunosuppressive myeloid cells hinder immunotherapeutic efficacy in tumors, but the precise mechanisms remain undefined. Here, by performing single-cell RNA sequencing in colorectal cancer tissues, we found tumor-associated macrophages and granulocytic myeloid-derived suppressor cells increased most compared to their counterparts in normal tissue and displayed the highest immune-inhibitory signatures among all immunocytes. These cells exhibited significantly increased expression of immunoreceptor tyrosine-based inhibitory motif-bearing receptors, including SIRPA. Notably, Sirpa mice were more resistant to tumor progression than wild-type mice. Moreover, Sirpα deficiency reprogramed the tumor microenvironment through expansion of TAM_Ccl8 and gMDSC_H2-Q10 subsets showing strong antitumor activity. Sirpa macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa macrophages facilitated T cell recruitment via Syk/Btk-dependent Ccl8 secretion. Therefore, Sirpα deficiency enhances innate and adaptive immune activation independent of expression of CD47 and Sirpα blockade could be a promising strategy to improve cancer immunotherapy efficacy.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	共同第一 ; 通讯
出版者	Springer Science and Business Media LLC
Scopus记录号	2-s2.0-85182172961
来源库	人工提交
引用统计	被引频次[WOS]：25
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/677974
专题	生命科学学院南方科技大学第一附属医院生命科学学院_系统生物学系
作者单位	1.Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Zhuhai, China 2.Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. 3.School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. 4.Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 5.GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China 6.Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen, China 7.Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China 8.State Key Laboratory Nature Cancer Article https://doi.org/10.1038/s43018-023-00691-z of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. 9.Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 10.Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 11.Department of Gastrointestinal Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China 12.Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University, Guangzhou, China 13.Jinfeng Laboratory, Chongqing, China. 14.CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
通讯作者单位	生命科学学院
推荐引用方式 GB/T 7714	Chunliu,Huang,Xuefei,Wang,Yingzhao,Wang,et al. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47[J]. Nature Cancer,2024.
APA	Chunliu,Huang.,Xuefei,Wang.,Yingzhao,Wang.,Yongyi,Feng.,Xiumei,Wang.,...&Wenfei,Jin.(2024).Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47.Nature Cancer.
MLA	Chunliu,Huang,et al."Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47".Nature Cancer (2024).

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