Thermoacoustic endoscopy

Liang，Xiao1,2; Guo，Heng1,2; Liu，Qiang1; Wu，Changfeng1; Gong，Yubin3; Xi，Lei1

2020-01-06

10.1063/1.5126880

APPLIED PHYSICS LETTERS   影响因子和分区

0003-6951

1077-3118

In this study, we developed microwave-induced thermoacoustic endoscopy (TAE), which employs a high-repetition-rate pulsed microwave generator for external excitation and a side-view focused ultrasound transducer for internal acoustic detection. The system yields a lateral resolution of 1.5 mm and an axial resolution of 0.35 mm. The penetration depths of saline-containing tube (5% NaCl) and tumor lesions in biological tissues are 9 and 6 cm under current experimental conditions, respectively. To improve the signal-to-noise ratio (SNR) of the reconstructed image and eliminate the off-focus distortion of the transducer, we applied the synthetic aperture focusing technique (SAFT) and coherence weighting factor into the reconstruction algorithm. Additionally, we carried out in vivo rat experiments to evaluate clinical feasibility of this technique. We could clearly distinguish multiple tumor lesions embedded inside the rat abdomen from the surrounding normal tissues.

SCI ; EI

英语

NI论文

第一

National Natural Science Foundation of China[61775028] ; National Natural Science Foundation of China[81571722] ; National Natural Science Foundation of China[61528401]

Physics

Physics, Applied

WOS:000518025000002

American Institute of Physics Inc.

20200408081884

Endoscopy ; Histology ; Image enhancement ; Microwave acoustics ; Rats ; Sodium chloride ; Synthetic apertures ; Thermoacoustics ; Transducers ; Tumors ; Ultrasonic applications ; Ultrasonic transducers

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Information Theory and Signal Processing:716.1 ; Radar Systems and Equipment:716.2 ; Acoustics, Noise. Sound:751 ; Ultrasonic Devices:753.2 ; Ultrasonic Applications:753.3

PHYSICS

2-s2.0-85078253092

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
2.School of Physics,University of Electronic Science and Technology of China,Chengdu, Sichuan,610054,China
3.School of Electrical Science and Engineering,University of Electronic Science and Technology of China,Chengdu, Sichuan,610054,China

Liang，Xiao,Guo，Heng,Liu，Qiang,et al. Thermoacoustic endoscopy[J]. APPLIED PHYSICS LETTERS,2020,116(1).

Liang，Xiao,Guo，Heng,Liu，Qiang,Wu，Changfeng,Gong，Yubin,&Xi，Lei.(2020).Thermoacoustic endoscopy.APPLIED PHYSICS LETTERS,116(1).

Liang，Xiao,et al."Thermoacoustic endoscopy".APPLIED PHYSICS LETTERS 116.1(2020).