| 题名 | VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification |
| 作者 | Yang，Yueli1; Jia，Wenqi2,3,4; Luo，Zhiwei2,3; Li，Yunpan2,3; Liu，Hao2,3; Fu，Lixin4,5; Li，Jinxiu4,5; Jiang，Yu1; Lai，Junjian2,3,5; Li，Haiwei6; Saeed，Babangida Jabir2,3; Zou，Yi5; Lv，Yuan2,3,5; Wu，Liang2,3; Zhou，Ting7; Shan，Yongli3; Liu，Chuanyu5; Lai，Yiwei5,8; Liu，Longqi5,8,9; Hutchins，Andrew P.10  ; Esteban，Miguel A.1,2,3,5,8 ; Mazid，Md Abdul2,3; Li，Wenjuan2,3
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| 通讯作者 | Esteban，Miguel A.; Mazid，Md Abdul; Li，Wenjuan |
| 发表日期 | 2024-12-01
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| DOI | |
| 发表期刊 | |
| EISSN | 2041-1723
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| 卷号 | 15期号:1 |
| 摘要 | In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta specification are understudied due to ethical barriers and the scarcity of embryos. Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophoblast stem cells (TSCs), offering a valuable in vitro model to study early placenta specification. Here, we demonstrate that the VGLL1 (vestigial-like family member 1), which is highly expressed during human and non-human primate TE specification in vivo but is negligibly expressed in mouse, is a critical regulator of cell fate determination and self-renewal in human TELCs and TSCs derived from naïve PSCs. Mechanistically, VGLL1 partners with the transcription factor TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibility at target gene loci through histone acetylation and acts in cooperation with GATA3 and TFAP2C. Our work is relevant to understand primate early embryogenesis and how it differs from other mammalian species. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| Scopus记录号 | 2-s2.0-85182705301
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：6
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/701272 |
| 专题 | 生命科学学院_系统生物学系 生命科学学院 |
| 作者单位 | 1.State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases,Key Laboratory for Zoonosis Research of the Ministry of Education,Institute of Zoonosis,and College of Veterinary Medicine,Jilin University,Changchun,China 2.Laboratory of Integrative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences (CAS),Guangzhou,China 3.CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,Guangzhou,China 4.University of Chinese Academy of Sciences,Beijing,China 5.BGI Research,Shenzhen,China 6.Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou Medical University,Guangzhou,China 7.Stem Cell Research Facility,Sloan Kettering Institute,New York,United States 8.BGI Research,Hangzhou,China 9.College of Life Sciences,University of Chinese Academy of Sciences,Beijing,China 10.Department of Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China |
| 推荐引用方式 GB/T 7714 |
Yang，Yueli,Jia，Wenqi,Luo，Zhiwei,et al. VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification[J]. Nature Communications,2024,15(1).
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| APA |
Yang，Yueli.,Jia，Wenqi.,Luo，Zhiwei.,Li，Yunpan.,Liu，Hao.,...&Li，Wenjuan.(2024).VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.Nature Communications,15(1).
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| MLA |
Yang，Yueli,et al."VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification".Nature Communications 15.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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