Recent advances on catalytic asymmetric hydrogenation of oximes and oxime ethers

Lu，Bin1; Yu，Jianchao1; Zhang，Xumu1; Chen，Gen Qiang1,2

2024-02-17

10.1016/j.tetlet.2024.154914

Tetrahedron Letters   影响因子和分区

0040-4039

1873-3581

The asymmetric hydrogenation of imines has been well-established; however, the asymmetric hydrogenation of oximes and oxime ethers with the retention of N–O bonds remains a significant challenge in the realm of asymmetric hydrogenation, due to the low reactivity and the difficulty in control of stereoselectivity. Catalytic asymmetric hydrogenation of oximes or oxime ethers represents one of the most direct and efficient method for the construction of chiral hydroxylamines, which are key structural motifs in a wide range of bioactive compounds and pharmaceuticals. This review describes the recent progress in the development of catalytic asymmetric hydrogenation of oximes and oxime ethers. We hope that this review will inspire the development of new synthetic strategies for the asymmetric synthesis of chiral hydroxylamines.

Asymmetric hydrogenation Enantioselectivity Hydroxylamines Metal-catalysed Oximes and oxime ethers

SCI

英语

第一

CHEMISTRY

2-s2.0-85183520061

Scopus

1.Medi-X Pingshan and Department of Chemistry,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Road,518055,China
2.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Road,518055,China

Lu，Bin,Yu，Jianchao,Zhang，Xumu,et al. Recent advances on catalytic asymmetric hydrogenation of oximes and oxime ethers[J]. Tetrahedron Letters,2024,136.

Lu，Bin,Yu，Jianchao,Zhang，Xumu,&Chen，Gen Qiang.(2024).Recent advances on catalytic asymmetric hydrogenation of oximes and oxime ethers.Tetrahedron Letters,136.

Lu，Bin,et al."Recent advances on catalytic asymmetric hydrogenation of oximes and oxime ethers".Tetrahedron Letters 136(2024).