Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products

Ding，Yuyang1; Xue，Xiaoqian2

2024-02-01

10.3390/molecules29030689

Molecules   影响因子和分区

1420-3049

Natural bioactive compounds are valuable resources for drug discovery due to their diverse and unique structures. However, these compounds often lack optimal drug-like properties. Therefore, structural optimization is a crucial step in the drug development process. By employing medicinal chemistry principles, targeted molecular operations can be applied to natural products while considering their size and complexity. Various strategies, including structural fragmentation, elimination of redundant atoms or groups, and exploration of structure-activity relationships, are utilized. Furthermore, improvements in physicochemical properties, chemical and metabolic stability, biophysical properties, and pharmacokinetic properties are sought after. This article provides a concise analysis of the process of modifying a few marketed drugs as illustrative examples.

drug discovery medicinal chemistry natural bioactive compounds structure-activity relationships

SCI

英语

通讯

CHEMISTRY

2-s2.0-85184472505

Scopus

1.Shenzhen Borui Pharmaceutical Technology Co.,Ltd.,Shenzhen,518055,China
2.Medi-X Pingshan,Southern University of Science and Technology,Shenzhen,518055,China

Ding，Yuyang,Xue，Xiaoqian. Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products[J]. Molecules,2024,29(3).

Ding，Yuyang,&Xue，Xiaoqian.(2024).Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products.Molecules,29(3).

Ding，Yuyang,et al."Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products".Molecules 29.3(2024).