南方科技大学知识苑(SUSTech KC): TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression

题名	TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression
作者	Guo，Lin 1,2; Liu，Jia jun 1; Long，Shao yuan 1; Wang，Pei yun 1; Li，Shan 3; Wang，Jin lan 1; Wei，Xia fei 4; Li，Jie 1; Lei，Ling 5; Huang，Ai long 1; Hu，Jie li 1
发表日期	2024-02-01
DOI	10.1002/jmv.29439
发表期刊	Journal of Medical Virology 影响因子和分区
ISSN	0146-6615
EISSN	1096-9071
卷号	96 期号:2
摘要	Hepatitis B virus (HBV) infection is a serious global health problem. After the viruses infect the human body, the host can respond to the virus infection by coordinating various cellular responses, in which mitochondria play an important role. Evidence has shown that mitochondrial proteins are involved in host antiviral responses. In this study, we found that the overexpression of TIM22 and TIM29, the members of the inner membrane translocase TIM22 complex, significantly reduced the level of intracellular HBV DNA and RNA and secreted HBV surface antigens and E antigen. The effects of TIM22 and TIM29 on HBV replication and transcription is attributed to the reduction of core promoter activity mediated by the increased expression of SRSF1 which acts as a suppressor of HBV replication. This study provides new evidence for the critical role of mitochondria in the resistance of HBV infection and new targets for the development of treatment against HBV infection.
关键词	HBV mitochondria SRSF1 TIM22 TIM29
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
ESI学科分类	MICROBIOLOGY
Scopus记录号	2-s2.0-85183915583
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/701476
专题	南方科技大学第二附属医院
作者单位	1.Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing,China 2.Department of Clinical Laboratory,Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College),Chengdu,China 3.Department of Clinical Laboratory,the Sixth Hospital of Chengdu,Chengdu,China 4.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,China 5.Chongqing Health Center for Women and Children,Women and Children's Hospital of Chongqing Medical University,Chongqing,China
推荐引用方式 GB/T 7714	Guo，Lin,Liu，Jia jun,Long，Shao yuan,et al. TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression[J]. Journal of Medical Virology,2024,96(2).
APA	Guo，Lin.,Liu，Jia jun.,Long，Shao yuan.,Wang，Pei yun.,Li，Shan.,...&Hu，Jie li.(2024).TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression.Journal of Medical Virology,96(2).
MLA	Guo，Lin,et al."TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression".Journal of Medical Virology 96.2(2024).