Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation

Dong，Ruihua1,4; Wang，Lulu2; Li，Zebin1; Jiao，Jincheng3; Wu，Yan1; Feng，Zhuowei1; Wang，Xufang2; Chen，Minglong3; Cui，Chang3; Lu，Yi2; Jiang，Xingyu1

2024-01-16

10.1021/acsnano.3c10028

ACS Nano   影响因子和分区

1936-0851

1936-086X

Implantable neuroelectronic interfaces have gained significant importance in long-term brain-computer interfacing and neuroscience therapy. However, due to the mechanical and geometrical mismatches between the electrode-nerve interfaces, personalized and compatible neural interfaces remain serious issues for peripheral neuromodulation. This study introduces the stretchable and flexible electronics class as a self-rolled neural interface for neurological diagnosis and modulation. These stretchable electronics are made from liquid metal-polymer conductors with a high resolution of 30 μm using microfluidic printing technology. They exhibit high conformability and stretchability (over 600% strain) during body movements and have good biocompatibility during long-term implantation (over 8 weeks). These stretchable electronics offer real-time monitoring of epileptiform activities with excellent conformability to soft brain tissue. The study also develops self-rolled microfluidic electrodes that tightly wind the deforming nerves with minimal constraint (160 μm in diameter). The in vivo signal recording of the vagus and sciatic nerve demonstrates the potential of self-rolled cuff electrodes for sciatic and vagus neural modulation by recording action potential and reducing heart rate. The findings of this study suggest that the robust, easy-to-use self-rolled microfluidic electrodes may provide useful tools for compatible neuroelectronics and neural modulation.

liquid metals microfluidic printing neural interfaces self-rolled bioelectronics vagus neuromodulation

SCI ; EI

英语

第一

2-s2.0-85181802754

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Road, Nanshan District, Guangdong,518055,China
2.CAS Key Laboratory of Brain Connectome and Manipulation,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen-Hong Kong Institute of Brain Science,Shenzhen,518055,China
3.Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,210000,China
4.School of Rehabilitation Sciences and Engineering,University of Health and Rehabilitation Sciences,Qingdao,No. 369, Dengyun Road, Gaoxin District, Shandong,266013,China

Dong，Ruihua,Wang，Lulu,Li，Zebin,et al. Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation[J]. ACS Nano,2024,18(2):1702-1713.

Dong，Ruihua.,Wang，Lulu.,Li，Zebin.,Jiao，Jincheng.,Wu，Yan.,...&Jiang，Xingyu.(2024).Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation.ACS Nano,18(2),1702-1713.

Dong，Ruihua,et al."Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation".ACS Nano 18.2(2024):1702-1713.