Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment

Wang，Jiazhen1,2; Qiu，Wenhui1,2; Cheng，Haodong1,3; Chen，Tao4; Tang，Yuanyuan1; Magnuson，Jason T.5; Xu，Xiangrong6; Xu，Elvis Genbo7; Zheng，Chunmiao1,3

2024-01-12

10.1021/acsestwater.3c00392

ACS ES and T Water   影响因子和分区

2690-0637

The global impact of nanoplastics (NPs) as emerging pollutants on water environments remains uncertain. Previous studies have focused on the toxicity of NPs itself, often ignoring the important effects of exposure routes. Here, we evaluated the impact of different exposure routes (waterborne, foodborne, and coexposure) of 80 nm polystyrene NPs on intestinal accumulation and inflammatory response using zebrafish. Our results demonstrated that aqueous and dietary exposures led to both time- and dose-dependent bioaccumulation of NPs, damaged intestinal structure, and induced immune cells and genes in the intestine. While waterborne exposure caused lower NPs accumulation than foodborne exposure, both demonstrated similar immunotoxicity in the intestine. In addition, co-exposure can lead to a higher accumulation of NPs and toxicity in zebrafish, suggesting that the risk of environmental exposure may be underestimated, as current toxicity assessments have focused on single-route exposure scenarios. We further revealed that NPs activated downstream genes of the toll-like 4 receptor, suggesting that NPs can cause an inflammatory response. Our study is the first known to report that exposure to NPs via different routes induces an accumulation in the intestine and can cause similar intestinal disturbance effects, providing new insights for adequately assessing the potential risks of NPs.

exposure routes food chain immunotoxicity intestine plastic pollution

ESCI

英语

第一 ; 通讯

2-s2.0-85181061691

Scopus

1.State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control,Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Avenue, Nanshan District,518055,China
2.Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Avenue, Nanshan District,518055,China
3.Eastern Institute for Advanced Study,Eastern Institute of Technology,Ningbo,315410,China
4.SCNU Environmental Research Institute,Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment,School of Environment,South China Normal University,Guangzhou,510006,China
5.Department of Chemistry,Bioscience and Environmental Engineering,University of Stavanger,Stavanger,Måltidets Hus─Richard Johnsens gate 4,4021,Norway
6.Key Laboratory of Tropical Marine Bio-Resources and Ecology,Guangdong Provincial Key Laboratory of Applied Marine Biology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou,510301,China
7.Department of Biology,University of Southern Denmark,Odense,Campusvej 55,5230,Denmark

Wang，Jiazhen,Qiu，Wenhui,Cheng，Haodong,et al. Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment[J]. ACS ES and T Water,2024,4(1):91-102.

Wang，Jiazhen.,Qiu，Wenhui.,Cheng，Haodong.,Chen，Tao.,Tang，Yuanyuan.,...&Zheng，Chunmiao.(2024).Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment.ACS ES and T Water,4(1),91-102.

Wang，Jiazhen,et al."Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment".ACS ES and T Water 4.1(2024):91-102.