Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model

Wang，Si Yun1; Tan，Xin2; Liu，Zi Qiang2; Ma，Hui3,4; Liu，Tian Bin3,4; Yang，Yong Qing2; Ying，Yong3,4; Gao，Ru Yue2; Zhang，Dai Zhou3,4; Ma，Ying Fei2; Chen，Kai3,4; Lin，Lin3,4; Jiang，Zhi Huan3,4; Yu，Jia Lin1,5

2024-01-11

10.1128/spectrum.01882-23

Microbiology spectrum   影响因子和分区

2165-0497

IMPORTANCE: Phage therapy is gaining traction as an alternative to antibiotics due to the rise of multi-drug-resistant (MDR) bacteria. This study assessed the pharmacokinetics and safety of PA_LZ7, a phage targeting MDR Pseudomonas aeruginosa, in mice. After intravenous administration, the phage showed an exponential decay in plasma and its concentration dropped significantly within 24 h for all dosage groups. Although there was a temporary increase in certain plasma cytokines and spleen weight at higher dosages, no significant toxicity was observed. Therefore, PA_LZ7 shows potential as an effective and safe candidate for future phage therapy against MDR P. aeruginosa infections.

antibiotic resistance phage therapy pharmacokinetics safety

英语

其他

2-s2.0-85182501225

Scopus

1.Department of Neonatology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing Key Laboratory of Pediatrics,China
2.Shenzhen Key Laboratory of Synthetic Genomics,Guangdong Provincial Key Laboratory of Synthetic Genomics,CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
3.New Drug Evaluation Center of Shandong Academy of Pharmaceutical Sciences,Shandong Academy of Pharmaceutical Sciences,Ji'nan,China
4.Shandong Innovation Center of Engineered Bacteriophage Therapeutics,Ji'nan,China
5.Department of Neonatology,Southern University of Science and Technology Hospital,Shenzhen,China

Wang，Si Yun,Tan，Xin,Liu，Zi Qiang,et al. Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model[J]. Microbiology spectrum,2024,12(1).

Wang，Si Yun.,Tan，Xin.,Liu，Zi Qiang.,Ma，Hui.,Liu，Tian Bin.,...&Yu，Jia Lin.(2024).Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model.Microbiology spectrum,12(1).

Wang，Si Yun,et al."Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model".Microbiology spectrum 12.1(2024).