南方科技大学知识苑(SUSTech KC): MDR-Chin study analysis: prospects of using all-oral short-course treatment regimens for multidrug-resistant pulmonary tuberculosis in China MDR-Chin 研究解析:耐多药肺结核全口服短程治疗方案在中国的应用前景

题名	MDR-Chin study analysis: prospects of using all-oral short-course treatment regimens for multidrug-resistant pulmonary tuberculosis in China MDR-Chin 研究解析:耐多药肺结核全口服短程治疗方案在中国的应用前景
作者	Fu，Liang; Deng，Guofang
通讯作者	Deng，Guofang
发表日期	2024-01-10
DOI	10.19982/j.issn.1000-6621.20230325
发表期刊	Chinese Journal of Antituberculosis 影响因子和分区
ISSN	1000-6621
卷号	46 期号:1页码:18-22
摘要	The global trend in the treatment of multidrug-resistant tuberculosis (MDR-TB) is to shorter treatment durations. The MDR-Chin study is China’s first cohort study to explore all-oral short-course regimens for the treatment of MDR-TB and pre-extensive drug-resistant tuberculosis (pre-XDR-TB), validating the efficacy and safety of three different treatment regimens. The results indicated that within a 12-month follow-up after the drug withdrawal, 96% of MDR-TB patients and 83.3% of pre-XDR-TB patients achieved favorable outcomes; the overall rate of favorable outcomes was 92.9%. Although grade 3 or higher adverse events (AEs) were quite common (48.1%), most were manageable and controllable, with relatively rare serious AEs (7.7%). In the study, loss-to-follow-up rate was low, the advantages of the all-oral short-course regimen were reflected and the potential for application in resource-limited settings was displayed. In this article, the author provides an overview of the MDR-Chin study, analyzesthe advantages and disadvantages, and discusses the application and future directions of clinical research for all-oral, short-course treatment regimens in China.
关键词	Clinical protocols Drug resistance multiple pulmonary Therapeutic uses Tuberculosis
相关链接	[Scopus记录]
语种	中文
学校署名	第一 ; 通讯
Scopus记录号	2-s2.0-85184764699
来源库	Scopus
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/701589
专题	南方科技大学第二附属医院
作者单位	Division Two of Pulmonary Diseases Department,Department of Pulmonary Medicine,Shenzhen Third People’s Hospital,National Clinical Research Center for Infectious Disease (Shenzhen),Shenzhen Clinical Research Center for Tuberculosis,Southern University of Science and Technology,Shenzhen,518000,China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Fu，Liang,Deng，Guofang. MDR-Chin study analysis: prospects of using all-oral short-course treatment regimens for multidrug-resistant pulmonary tuberculosis in China MDR-Chin 研究解析:耐多药肺结核全口服短程治疗方案在中国的应用前景[J]. Chinese Journal of Antituberculosis,2024,46(1):18-22.
APA	Fu，Liang,&Deng，Guofang.(2024).MDR-Chin study analysis: prospects of using all-oral short-course treatment regimens for multidrug-resistant pulmonary tuberculosis in China MDR-Chin 研究解析:耐多药肺结核全口服短程治疗方案在中国的应用前景.Chinese Journal of Antituberculosis,46(1),18-22.
MLA	Fu，Liang,et al."MDR-Chin study analysis: prospects of using all-oral short-course treatment regimens for multidrug-resistant pulmonary tuberculosis in China MDR-Chin 研究解析:耐多药肺结核全口服短程治疗方案在中国的应用前景".Chinese Journal of Antituberculosis 46.1(2024):18-22.