Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration

Wang，Kui1,2; Ge，Yongmei1; Yang，Yongshuai1; Li，Zhenjian1; Liu，Jiayi1; Xue，Yizebang1; Zhang，Yuanjun1; Pang，Xiangchao3,4; Ngan，A. H.W.2; Tang，Bin1,3

2024

10.1093/rb/rbae004

Regenerative Biomaterials   影响因子和分区

2056-3418

2056-3426

Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction, and this leads to various clinical complications including diabetic foot ulcers. The vascular endothelial cells, which compactly line the inner surface of blood vessels, are responsible for the growth and maintenance of blood vessels and play an essential role in tissue regeneration. Although the mechanical properties of cells are generally known to be regulated by physiological/pathological conditions, few studies have been performed to investigate vascular endothelial cellular mechanics under hyperglycemia and the biological functions related to tissue regeneration. In this study, we conduct a systematic investigation of this issue. The results suggested that the stiffness of human umbilical vein endothelial cells (HUVECs) can be significantly regulated by the glucose concentration, subsequently, leading to significant alterations in cell migration and proliferation capabilities that are closely related to tissue regeneration. The rearrangement of the cytoskeleton induced by hyperglycemia through Cdc42 was found to be one of the pathways for the alteration of the cell stiffness and the subsequent cell dysfunctions. Therefore, we suggested that the inhibition of Cdc42 might be a promising strategy to facilitate various tissue regeneration for diabetes patients. (Figure Presented)

Cdc42 endothelial cell hyperglycemia migration stiffness

SCI ; EI

英语

第一

2-s2.0-85184807169

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Mechanical Engineering,University of Hong Kong,Hong Kong,999077,Hong Kong
3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen,518055,China
4.College of Materials Science and Engineering,Central South University of Forestry and Technology,Changsha,410004,China

Wang，Kui,Ge，Yongmei,Yang，Yongshuai,et al. Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration[J]. Regenerative Biomaterials,2024,11.

Wang，Kui.,Ge，Yongmei.,Yang，Yongshuai.,Li，Zhenjian.,Liu，Jiayi.,...&Tang，Bin.(2024).Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration.Regenerative Biomaterials,11.

Wang，Kui,et al."Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration".Regenerative Biomaterials 11(2024).