| 题名 | Total Synthesis of Incarnatapeptins A and B |
| 作者 | |
| 通讯作者 | Guo，Yian |
| 发表日期 | 2024
|
| DOI | |
| 发表期刊 | |
| ISSN | 1433-7851
|
| EISSN | 1521-3773
|
| 卷号 | 63期号:9 |
| 摘要 | The first total synthesis of incarnatapeptins A and B, two novel marine natural products, was accomplished from readily available (S)-1-benzyloxycarbonylhexahydropyridazine-3-carboxylic acid. This route, whose longest linear sequence was 12 steps, provided the incarnatapeptins A and B in yields of 26.5 % and 19.7 %, respectively, and enabled the structure and stereochemistry of both natural products to be unambiguously confirmed. Highlights of our synthesis include the photoredox-mediated decarboxylative 1,4-addition reaction and a novel and practical N-acylation paradigm promoted by silver carbonate. The unusual facile atropisomerism of some linear peptidic intermediates was also observed by TLC analysis in the course of this work. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 其他
|
| 资助项目 | National Natural Science Foundation of China["22171014","21901013"]
; The 2022 Shenzhen Sustainable Supporting Funds for Colleges and Universities[20220811103834002]
; Guangdong Natural Science Foundation[2021 A1515010344]
; Guangdong Department of Education[2021ZDJS097]
; Science, Technology & Innovation Bureau of Longgang District[RCTDPT-2019-008]
|
| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Multidisciplinary
|
| WOS记录号 | WOS:001153405700001
|
| 出版者 | |
| ESI学科分类 | CHEMISTRY
|
| Scopus记录号 | 2-s2.0-85183926481
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：2
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/701713 |
| 专题 | 南方科技大学 |
| 作者单位 | 1.State Key Laboratory of Chemical Oncogenomics,Peking University Shenzhen Graduate School,Xili,Shenzhen,Nanshan District,518055,China 2.QianYan (Shenzhen) Pharmatech. Ltd.,Shenzhen,518172,China 3.Southern University of Science and Technology,Shenzhen,518055,China |
| 推荐引用方式 GB/T 7714 |
Han，Feipeng,Li，Jie,Li，Shupeng,et al. Total Synthesis of Incarnatapeptins A and B[J]. Angewandte Chemie - International Edition,2024,63(9).
|
| APA |
Han，Feipeng,Li，Jie,Li，Shupeng,Wang，Zhuo,Guo，Yian,&Ye，Tao.(2024).Total Synthesis of Incarnatapeptins A and B.Angewandte Chemie - International Edition,63(9).
|
| MLA |
Han，Feipeng,et al."Total Synthesis of Incarnatapeptins A and B".Angewandte Chemie - International Edition 63.9(2024).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
;
修改评论