Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds

Huang，Da1,2; Du，Jiahao1; Luo，Fang1,2; He，Gang3; Zou，Minglang1; Wang，Yongming1; Lin，Zhenyu2; Wu，Decheng3; Weng，Zuquan1,4

2024

10.1002/adhm.202303379

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly(L-lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 ∼ 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management.

chronic wounds hydrogels on-demand treatment pH detection ultrasound responsive wound monitoring

SCI ; EI

英语

其他

2-s2.0-85182455618

Scopus

1.College of Biological Science and Engineering,Fuzhou University,Fuzhou,Fujian,350108,China
2.Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology,Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety,College of Chemistry,Fuzhou University,Fuzhou,Fujian,350108,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.Department of Plastic Surgery,the First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian,350005,China

Huang，Da,Du，Jiahao,Luo，Fang,et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds[J]. Advanced Healthcare Materials,2024.

Huang，Da.,Du，Jiahao.,Luo，Fang.,He，Gang.,Zou，Minglang.,...&Weng，Zuquan.(2024).Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds.Advanced Healthcare Materials.

Huang，Da,et al."Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds".Advanced Healthcare Materials (2024).