Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury

Zhang，Xuefeng1,2,3; Huang，Xuyang4; Hang，Diancheng2; Jin，Jiaqi2; Li，Shanshan5; Zhu，Yufu2,3; Liu，Hongmei1,2

2024

10.1126/sciadv.adj4260

Science Advances   影响因子和分区

2375-2548

2375-2548

Posttraumatic neuroinflammation is a key driver of secondary injury after traumatic brain injury (TBI). Pyroptosis, a proinflammatory form of programmed cell death, considerably activates strong neuroinflammation and amplifies the inflammatory response by releasing inflammatory contents. Therefore, treatments targeting pyroptosis may have beneficial effects on the treatment of secondary brain damage after TBI. Here, a cysteine-alanine-glutamine-lysine peptide–modified β-lactoglobulin (β-LG) nanoparticle was constructed to deliver disulfiram (DSF), C-β-LG/ DSF, to inhibit pyroptosis and decrease neuroinflammation, thereby preventing TBI-induced secondary injury. In the post-TBI mice model, C-β-LG/DSF selectively targets the injured brain, increases DSF accumulation, and extends the time of the systemic circulation of DSF. C-β-LG/DSF can alleviate brain edema and inflammatory response, inhibit secondary brain injury, promote learning, and improve memory recovery in mice after trauma. Therefore, this study likely provided a potential approach for reducing the secondary spread of TBI.

SCI ; EI

英语

第一

Social development Project of Jiangsu department of Science and technology[Be2020647] ; Shenzhen Basic Research Project[JcYJ20220530114409020] ; Public Welfare Research Project in Jiaxing city[2023AY310080] ; Scientific Research Project of health commission of Jiangsu Province[M2021062] ; Xuzhou Medical leading talents training Project[XWRcht20210031]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001139921200006

AMER ASSOC ADVANCEMENT SCIENCE

2-s2.0-85182096857

Scopus

1.department of Biomedical engineering,Southern University of Science and technology,Shenzhen,no. 1088, Xueyuan Avenue,518055,China
2.institute of nervous System diseases,Xuzhou Medical University,Xuzhou,no. 84 huaihai Xi Road,221002,China
3.department of neurosurgery,Affiliated hospital of Xuzhou Medical University,Xuzhou,no. 99 huaihai Xi Road,221002,China
4.department of intensive care Medicine,the Second hospital of Jiaxing,Jiaxing,no.1518, huancheng north Road, Zhejiang,314099,China
5.department of Forensic Medicine,Xuzhou Medical University,Xuzhou,no. 84 huaihai Xi Road,221002,China

Zhang，Xuefeng,Huang，Xuyang,Hang，Diancheng,et al. Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury[J]. Science Advances,2024,10(2).

Zhang，Xuefeng.,Huang，Xuyang.,Hang，Diancheng.,Jin，Jiaqi.,Li，Shanshan.,...&Liu，Hongmei.(2024).Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury.Science Advances,10(2).

Zhang，Xuefeng,et al."Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury".Science Advances 10.2(2024).