| 题名 | The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism |
| 作者 | |
| 通讯作者 | Zhao，Qiao |
| 发表日期 | 2024-01-10
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| DOI | |
| 发表期刊 | |
| EISSN | 2375-2548
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| 卷号 | 10期号:2 |
| 摘要 | The aromatic amino acids (AAAs) phenylalanine, tyrosine, and tryptophan are basic protein units and precursors of diverse specialized metabolites that are essential for plant growth. Despite their significance, the mechanisms that regulate AAA homeostasis remain elusive. Here, we identified a cytosolic aromatic aminotransferase, REVERSAL OF SAV3 PHENOTYPE 1 (VAS1), as a suppressor of arogenate dehydrogenase 2 (adh2) in Arabidopsis (Arabidopsis thaliana). Genetic and biochemical analyses determined that VAS1 uses AAAs as amino donors, leading to the formation of 3-carboxyphenylalanine and 3-carboxytyrosine. These pathways represent distinct routes for AAA metabolism that are unique to specific plant species. Furthermore, we show that VAS1 is responsible for cytosolic AAA biosynthesis, and its enzymatic activity can be inhibited by 3-carboxyphenylalanine. These findings provide valuable insights into the crucial role of VAS1 in producing 3-carboxy AAAs, notably via recycling of AAAs in the cytosol, which maintains AAA homeostasis and allows plants to effectively coordinate the complex metabolic and biosynthetic pathways of AAAs. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| Scopus记录号 | 2-s2.0-85182095597
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：5
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/701904 |
| 专题 | 南方科技大学-北京大学植物与食品联合研究所 生命科学学院 生命科学学院_生物系 |
| 作者单位 | 1.Shenzhen Key laboratory of Synthetic Genomics,Guangdong Provincial Key laboratory of Synthetic Genomics,Key laboratory of Quantitative Synthetic Biology,Shenzhen institute of Synthetic Biology,Shenzhen institute of Advanced technology,chinese Academy of Sciences,Shenzhen,518055,China 2.center for Plant Biology,School of life Sciences,tsinghua University,Beijing,100084,China 3.University of chinese Academy of Sciences,Beijing,100049,China 4.State Key laboratory of drug Research,Shanghai institute of Materia Medica,chinese Academy of Sciences,Shanghai,201203,China 5.cAS Key laboratory for Quantitative engineering Biology,Shenzhen institute of Synthetic Biology,Shenzhen institute of Advanced technology,chinese Academy of Sciences,Shenzhen,518055,China 6.State Key laboratory of Bioactive Substances and Functions of natural Medicines,Beijing Key laboratory of Active Substances discovery and druggability evaluation,department of Medicinal chemistry,institute of Materia Medica,Peking Union Medical college,chinese Academy of Medical Sciences,Beijing,100050,China 7.State Key laboratory of Plant cell and chromosome engineering,cAS centre for excellence in Molecular Plant Biology,institute of Genetics and developmental Biology,the innovative Academy of Seed design,chinese Academy of Sciences,Beijing,100101,China 8.Key laboratory of Molecular design for Plant cell Factory of Guangdong higher education institutes,department of Biology,School of life Sciences,SUStech-PKU institute of Plant and Food Science,Southern University of Science and technology,Shenzhen,518055,China 9.innovation center of Pesticide Research,department of Applied chemistry,college of Science,china Agricultural University,Beijing,100193,China |
| 推荐引用方式 GB/T 7714 |
Wu，Jie,Chen，Yanhong,Huang，Yuxin,et al. The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism[J]. Science Advances,2024,10(2).
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| APA |
Wu，Jie.,Chen，Yanhong.,Huang，Yuxin.,Hao，Bingbing.,Dai，Shengkun.,...&Zhao，Qiao.(2024).The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.Science Advances,10(2).
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| MLA |
Wu，Jie,et al."The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism".Science Advances 10.2(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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