The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Shi-Yan Sun1,2; Lingyun Nie1,3; Jing Zhang4,5; Xue Fang1; Hongmei Luo1,2; Chuanhai Fu1,3; zhiyi Wei4,5; Ai-Hui Tang1,2

2023-12-21

0.4103/1673-5374.391301

NEURAL REGENERATION RESEARCH   影响因子和分区

1673-5374

1876-7958

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and memory. Kinesin-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1; however, whether KIF21A modulates dendritic structure and function in neurons remains unknown. In this study, we found that KIF21A was distributed in a subset of dendritic spines, and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative spines. Furthermore, the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic plasticity. Knockdown of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching, and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1, but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and talin1. Knocking down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals' cognitive abilities. Taken together, our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

SCI

英语

其他

National Key Research and Development Program of China[2021ZD0202503] ; National Natural Science Foundation of China["31872759","32070707"] ; Shenzhen Science and Technology Program[RCJC20210609104333007] ; Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Fundamental Research Institutions[2021SHIBS0002]

Cell Biology ; Neurosciences & Neurology

Cell Biology ; Neurosciences

WOS:001220747500021

WOLTERS KLUWER MEDKNOW PUBLICATIONS

人工提交

1.Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Ministry of Education Key Laboratory for Membraneless Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, China
2.Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, Anhui Province, China
3.CAS Center for Excellence in Molecular Cell Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, China
4.Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong Province, China
5.5 Brain Research Center, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

Shi-Yan Sun,Lingyun Nie,Jing Zhang,et al. The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons[J]. NEURAL REGENERATION RESEARCH,2023,19(1).

Shi-Yan Sun.,Lingyun Nie.,Jing Zhang.,Xue Fang.,Hongmei Luo.,...&Ai-Hui Tang.(2023).The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons.NEURAL REGENERATION RESEARCH,19(1).

Shi-Yan Sun,et al."The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons".NEURAL REGENERATION RESEARCH 19.1(2023).