Polydopamine-Modied 2D Iron (II) Immobilized MnPS3 Nanosheets for Multimodal Imaging-Guided Cancer Synergistic Photothermal-Chemodynamic Therapy.

Hanhan Xie/Ming Yang,/Xiaoli He/Zhen Zhan,/Huaide Jiang/Yanmei Ma/Chengzhi Hu

2023-12

10.1002/advs.202306494

Advanced Science   影响因子和分区

2198-3844

Manganese phosphosulphide (MnPS), a newly emerged and promising member of the 2D metal phosphorus trichalcogenides (MPX) family, has aroused abundant interest due to its unique physicochemical properties and applications in energy storage and conversion. However, its potential in the field of biomedicine, particularly as a nanotherapeutic platform for cancer therapy, has remained largely unexplored. Herein, a 2D “all-in-one” theranostic nanoplatform based on MnPS is designed and applied for imaging-guided synergistic photothermal-chemodynamic therapy. (Iron) Fe (II) ions are immobilized on the surface of MnPS nanosheets to facilitate effective chemodynamic therapy (CDT). Upon surface modification with polydopamine (PDA) and polyethylene glycol (PEG), the obtained Fe-MnPS/PDA-PEG nanosheets exhibit exceptional photothermal conversion efficiency (η = 40.7%) and proficient pH/NIR-responsive Fenton catalytic activity, enabling efficient photothermal therapy (PTT) and CDT. Importantly, such nanoplatform can also serve as an efficient theranostic agent for multimodal imaging, facilitating real-time monitoring and guidance of the therapeutic process. After fulfilling the therapeutic functions, the Fe-MnPS/PDA-PEG nanosheets can be efficiently excreted from the body, alleviating the concerns of long-term retention and potential toxicity. This work presents an effective, precise, and safe 2D “all-in-one” theranostic nanoplatform based on MnPS for high-efficiency tumor-specific theranostics.

2D nanomaterials cancer theranostics chemodynamic therapy MnPS3 nanosheets photothermal therapy

SCI ; EI

英语

第一

2-s2.0-85179333418

人工提交

Southern University of Science and Technology

Hanhan Xie/Ming Yang,/Xiaoli He/Zhen Zhan,/Huaide Jiang/Yanmei Ma/Chengzhi Hu. Polydopamine-Modied 2D Iron (II) Immobilized MnPS3 Nanosheets for Multimodal Imaging-Guided Cancer Synergistic Photothermal-Chemodynamic Therapy.[J]. Advanced Science,2023,11(7).

Hanhan Xie/Ming Yang,/Xiaoli He/Zhen Zhan,/Huaide Jiang/Yanmei Ma/Chengzhi Hu.(2023).Polydopamine-Modied 2D Iron (II) Immobilized MnPS3 Nanosheets for Multimodal Imaging-Guided Cancer Synergistic Photothermal-Chemodynamic Therapy..Advanced Science,11(7).

Hanhan Xie/Ming Yang,/Xiaoli He/Zhen Zhan,/Huaide Jiang/Yanmei Ma/Chengzhi Hu."Polydopamine-Modied 2D Iron (II) Immobilized MnPS3 Nanosheets for Multimodal Imaging-Guided Cancer Synergistic Photothermal-Chemodynamic Therapy.".Advanced Science 11.7(2023).