Physical activity and sleep pattern in relation to incident Parkinson’s disease: a cohort study

Chen，Li Hua1,2; Sun，Shi Yu2; Li，Guijie1; Gao，Xiang3,4; Luo，Weifeng5; Tian，Haili6; Zhang，Xuanhao1; Yin，Xi1; Liu，Ziwei1; Chen，Guo Chong7; Xu，Guangfei1; Liu，Tong2; Li，Fu Rong8

2024-12-01

10.1186/s12966-024-01568-9

International Journal of Behavioral Nutrition and Physical Activity   影响因子和分区

1479-5868

Background: How physical activity (PA) and different sleep traits and overall sleep pattern interact in the development of Parkinson’s disease (PD) remain unknown. Objective: To prospectively investigate the joint associations of PA and sleep pattern with risk of PD. Methods: Included were 339,666 PD-free participants from the UK Biobank. Baseline PA levels were grouped into low (< 600 MET-mins/week), medium (600 to < 3000 MET-mins/week) and high (≥ 3000 MET-mins/week) according to the instructions of the UK Biobank. Healthy sleep traits (chronotype, sleep duration, insomnia, snoring, and daytime sleepiness) were scored from 0 to 5 and were categorized into “ideal sleep pattern” (≥ 3 sleep scores) and “poor sleep pattern” (0–2 sleep scores). Hazard ratios (HRs) and 95% confidence intervals (CIs) of PD were estimated by Cox proportional hazards models. Results: During a median of 11.8 years of follow-up, 1,966 PD events were identified. The PD risk was lower in participants with high PA (HR = 0.73; 95% CI: 0.64, 0.84), compared to those with low PA; and participants with ideal sleep pattern also had a lower risk of PD (HR = 0.78; 95% CI: 0.69, 0.87), compared to those with poor sleep pattern. When jointly investigating the combined effect, participants with both high PA and ideal sleep pattern had the lowest risk of incident PD (HR = 0.55; 95% CI: 0.44, 0.69), compared to those with low PA and poor sleep pattern; notably, participants with high PA but poor sleep pattern also gained benefit on PD risk reduction (HR = 0.74; 95% CI: 0.55, 0.99). Conclusions: Both high PA and ideal sleep pattern were independently associated with lower risk of developing PD, and those with both high PA level and ideal sleep pattern had the lowest risk. Our results suggest that improving PA levels and sleep quality may be promising intervention targets for the prevention of PD.

Joint association Parkinson’s disease Physical activity Sleep pattern UK Biobank

SCI

英语

其他

2-s2.0-85185283952

Scopus

1.Department of Nutrition and Food Hygiene,School of Public Health,Nantong University,Nantong,China
2.Institute of Pain Medicine and Special Environmental Medicine,Nantong University,Nantong,9 Seyuan Road, Chongchuan District,226019,China
3.Department of Nutritional Sciences,The Pennsylvania State University,State College,16801,United States
4.Department of Nutrition and Food Hygiene,School of Public Health,Institute of Nutrition,Fudan University,Shanghai,China
5.Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,China
6.School of Exercise and Health,Shanghai University of Sport,Shanghai,China
7.Department of Nutrition and Food Hygiene,School of Public Health,Suzhou Medical College of Soochow University,Suzhou,China
8.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Avenue, Fuguang community, Taoyuan Street, Nanshan District,China

Chen，Li Hua,Sun，Shi Yu,Li，Guijie,等. Physical activity and sleep pattern in relation to incident Parkinson’s disease: a cohort study[J]. International Journal of Behavioral Nutrition and Physical Activity,2024,21(1).

Chen，Li Hua.,Sun，Shi Yu.,Li，Guijie.,Gao，Xiang.,Luo，Weifeng.,...&Li，Fu Rong.(2024).Physical activity and sleep pattern in relation to incident Parkinson’s disease: a cohort study.International Journal of Behavioral Nutrition and Physical Activity,21(1).

Chen，Li Hua,et al."Physical activity and sleep pattern in relation to incident Parkinson’s disease: a cohort study".International Journal of Behavioral Nutrition and Physical Activity 21.1(2024).