Patterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey

Zhang，Jiaosheng1; Lin，Li2; Lu，Gen3; Wu，Keye4; Tian，Daiyin5; Tang，Lanfang6; Ma，Xiang7; Wang，Yajuan8; Liu，Gang9; Li，Yanqi10; Qian，Jing11; Wang，Ping12; Cao，Qing13; Zhang，Wenshuang14; Wu，Lijuan15; Si，Ligang16; Wu，Yue17; Zheng，Yuejie18; Shen，Kunling19,20; Deng，Jikui1; Li，Defa21,22; Yang，Yonghong23

2024-12-01

10.1186/s12879-024-09077-7

BMC Infectious Diseases   影响因子和分区

1471-2334

Objectives: In this study, we describe the patterns of antibiotic prescription for neonates based on World Health Organization’s (WHO) Essential Medicines List Access, Watch, and Reserve (AWaRe), and the Management of Antibiotic Classification (MAC) Guidelines in China. Methods: One-day point-prevalence surveys (PPS) on antimicrobial prescriptions were conducted on behalf of hospitalized neonates in China from September 1 and November 30, annually from 2017 to 2019. Results: Data was collected for a total of 2674 neonatal patients from 15 hospitals in 9 provinces across China of which 1520 were newborns who received at least one antibiotic agent. A total of 1943 antibiotic prescriptions were included in the analysis. The most commonly prescribed antibiotic was meropenem (11.8%). The most common reason for prescribing antibiotic to neonates was pneumonia (44.2%). There were 419 (21.6%), 1343 (69.1%) and 6 (0.3%) antibiotic prescriptions in the Access, Watch and Reserve groups, respectively. According to MAC Guidelines in China, there were 1090 (56.1%) antibiotic agents in the Restricted and 414 (21.3%) in the Special group. Conclusion: Broad-spectrum antibiotics included in the Watch and Special groups were likely to be overused in Chinese neonates.

Antibiotic China Neonates Pattern Prescription

SCI

英语

其他

IMMUNOLOGY

2-s2.0-85185128678

Scopus

1.Department of Infectious diseases,Shenzhen Children’s Hospital,Shenzhen,China
2.Department of Respiratory,The Second Affiliated Hospital & amp; Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
3.Department of Respiratory,Guangzhou Women and Children’s Medical Center,Guangzhou,China
4.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
5.Department of Respiratory,Children’s Hospital of Chongqing Medical University,Chongqing,China
6.Department of Respiratory,Children’s Hospital Zhejiang University School of Medicine,Hangzhou,China
7.Department of Respiratory,Children’s Hospital Affiliated to Shandong University & amp; Jinan Children’s Hospital,Jinan,China
8.Neonatal Department,Children’s Hospital Attached to the Capital Institute of Pediatrics,Beijing,China
9.Department of Infectious Diseases,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing,China
10.Department of Respiratory,Xi’an Children’s Hospital,Xi’an,China
11.Department of Respiratory,Children’s Hospital Attached to the Capital Institute of Pediatrics,Beijing,China
12.Neonatal Department,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,China
13.Department of Infectious Diseases,Shanghai Children’s Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai,China
14.Department of Respiratory,Tianjin Children’s Hospital,Tianjin,China
15.Clinical Laboratory,Bao’an Maternity & amp; Child Health Hospital,Shenzhen,China
16.Department of Pediatric,The sixth Hospital of Haerbin Medical University,Haerbin,China
17.Department of Pharmacy,Shenzhen Children’s Hospital,Shenzhen,China
18.Department of Respiratory,Shenzhen Children’s Hospital,Shenzhen,China
19.Department of Internal Medicine,Shenzhen Children’s Hospital,Shenzhen,China
20.Department of Respiratory,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing,China
21.Shenzhen Clinical College of Pediatrics,Shantou University Medical College,Shenzhen,China
22.Clinical laboratory,Shenzhen Children’s Hospital,Shenzhen,China
23.Beijing Pediatric Research Institute,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing,China

Zhang，Jiaosheng,Lin，Li,Lu，Gen,et al. Patterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey[J]. BMC Infectious Diseases,2024,24(1).

Zhang，Jiaosheng.,Lin，Li.,Lu，Gen.,Wu，Keye.,Tian，Daiyin.,...&Yang，Yonghong.(2024).Patterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey.BMC Infectious Diseases,24(1).

Zhang，Jiaosheng,et al."Patterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey".BMC Infectious Diseases 24.1(2024).