Catalytic enantioselective N-silylation of sulfoximine

Huang，Xingfen1; Zhu，Jiefeng1; He，Chuan1,2

2024-04-01

10.1016/j.cclet.2023.108783

Chinese Chemical Letters   影响因子和分区

1001-8417

A rhodium/diphosphine-catalyzed asymmetric cross-dehydrogenative coupling between sulfoximines and dihydrosilanes has been achieved. This is the first report on the enantioselective N-silylation of sulfoximines. The protocol gives access to a variety of Si-stereogenic N-silylated sulfoximines in decent yield (up to 99%) with excellent stereoselectivity (up to 99%), featuring high atom economy, and a cleaner manner with H as the sole byproduct. The obtained bis-Si-stereogenic monohydrosilane product can be further converted into the corresponding chiral polymer with pendant sulfoximine groups.

Asymmetric catalysis Chiral silylamine N-Silylation of sulfoximine Si-CADC Si-stereogenic silanes

SCI

英语

第一 ; 通讯

CHEMISTRY

2-s2.0-85185152467

Scopus

1.Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China
2.Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University,Hangzhou,311121,China

Huang，Xingfen,Zhu，Jiefeng,He，Chuan. Catalytic enantioselective N-silylation of sulfoximine[J]. Chinese Chemical Letters,2024,35(4).

Huang，Xingfen,Zhu，Jiefeng,&He，Chuan.(2024).Catalytic enantioselective N-silylation of sulfoximine.Chinese Chemical Letters,35(4).

Huang，Xingfen,et al."Catalytic enantioselective N-silylation of sulfoximine".Chinese Chemical Letters 35.4(2024).