Achieving beyond 100% Triplet State Generation with Singlet Fission Strategy for High-Performance Photosensitizer Design

Liu，Yubo1; Li，Jianqing1; Gong，Shaokuan2; Yu，Yuewen1; Zhu，Zhong Hong1; Ji，Chao1; Zhao，Zujin1; Chen，Xihan2; Feng，Guangxue1; Tang，Ben Zhong3

2024-03-04

10.1021/acsmaterialslett.4c00162

ACS Materials Letters   影响因子和分区

2639-4979

As the key of photodynamic therapy (PDT), the current photosensitizer (PS) design highly relies on promoting the intersystem crossing (ISC) process to form the triplet excited state, thus generating toxic reactive oxygen species (ROS). However, ISC is a spin-forbidden process with a low triplet state generation yield (<100%). Herein, as a proof of concept, we report a new strategy of aggregation induced singlet fission (SF) process with an ultrafast rate (<100 ps) and a very high triplet yield (>100%) to design efficient PSs. Such a unique SF strategy is demonstrated with an anthracene derivative of BPA-An, which shows J-aggregation enhanced ROS generation ability. Mechanism studies with aggregation behavior and fs-transient absorption spectroscopy indicate that BPA-An in J-aggregate state can efficiently generate triplet state via the SF process with a 158% triplet yield and thus possesses excellent Type-I and Type-II ROS generation ability in nanoparticle (NP) format. Both cellular and animal experiments further prove the excellent PDT antitumor performance of BPA-An NPs. To the best of our knowledge, this work shall represent the first example of utilizing SF as the design rule to promote the triplet state generation of PSs, which shall pave a new avenue in PDT.

SCI ; EI

英语

其他

2-s2.0-85185247848

Scopus

1.State Key Laboratory of Luminescent Materials and Devices,Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,School of Materials Science and Engineering,South China University of Technology,Guangzhou,Guangdong,510640,China
2.Shenzhen Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems,SUSTech Energy Institute for Carbon Neutrality,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
3.School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,Guangdong,518172,China

Liu，Yubo,Li，Jianqing,Gong，Shaokuan,et al. Achieving beyond 100% Triplet State Generation with Singlet Fission Strategy for High-Performance Photosensitizer Design[J]. ACS Materials Letters,2024,6(3):896-907.

Liu，Yubo.,Li，Jianqing.,Gong，Shaokuan.,Yu，Yuewen.,Zhu，Zhong Hong.,...&Tang，Ben Zhong.(2024).Achieving beyond 100% Triplet State Generation with Singlet Fission Strategy for High-Performance Photosensitizer Design.ACS Materials Letters,6(3),896-907.

Liu，Yubo,et al."Achieving beyond 100% Triplet State Generation with Singlet Fission Strategy for High-Performance Photosensitizer Design".ACS Materials Letters 6.3(2024):896-907.