Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis

Zhang，Fuhao1; Chen，Gen Qiang2; Zhang，Xumu1

2024-03-01

10.1021/acs.orglett.3c03068

Organic Letters   影响因子和分区

1523-7060

1523-7052

An extremely concise, scalable, and stereoselective synthesis of a privileged chiral skeleton based on 2,2′-biindolyl and commercially available chiral building blocks has been developed. This novel skeleton allows for easy access to a range of bisphosphine ligands (decagram scale, up to 58% total yield, only three steps). The synthetic method is characterized by an efficient central-to-axial chirality transfer strategy. In particular, the superior performance of the ligands has been demonstrated in diverse reactions, including several asymmetric hydrogenations, asymmetric conjugate reductions, and cycloisomerization reactions, indicating a great potential for the application of the newly developed chiral backbones in further modifications and exploration of novel chiral ligands and catalysts.

SCI

英语

第一

CHEMISTRY

2-s2.0-85186074781

Scopus

1.Medi-X Pingshan and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518000,China
2.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518000,China

Zhang，Fuhao,Chen，Gen Qiang,Zhang，Xumu. Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis[J]. Organic Letters,2024,26(8):1623-1628.

Zhang，Fuhao,Chen，Gen Qiang,&Zhang，Xumu.(2024).Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis.Organic Letters,26(8),1623-1628.

Zhang，Fuhao,et al."Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis".Organic Letters 26.8(2024):1623-1628.