南方科技大学知识苑(SUSTech KC): Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization

题名	Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization
作者	Xie，Tao 1; Zhu，Bin2 ; Li，Hao ran 1; Xu，Jin feng 3,4; Mao，Ying 1
通讯作者	Mao，Ying
发表日期	2024-03-01
DOI	10.1016/j.socscimed.2024.116680
发表期刊	Social Science and Medicine 影响因子和分区
ISSN	0277-9536
EISSN	1873-5347
卷号	345
摘要	Previous studies have reported the relationship between educational attainment and attention deficit hyperactivity disorder (ADHD). However, the mechanism of this relationship remains unknown. It is well known that educational attainment correlates with income. Therefore, based on summary data from a genome-wide association study we used two-step Mendelian randomization (MR) to explore the role of income between education and ADHD. The inverse variance weighted (IVW) method was used in our analysis. The IVW results suggested that educational attainment and income were protective factors against ADHD. Educational attainment affects ADHD through income [ADHD: Beta = −0.68, 95% confidence interval (CI) = −0.87, −0.49; female: Beta = −0.87, 95% CI = −1.28, −0.47; male: Beta = −1.01, 95% CI = −1.34, −0.68; childhood: Beta = −0.52, 95% CI = −0.74, −0.30; late-diagnosed: Beta = −0.78, 95% CI = −1.11, −0.47; persistent: Beta = −0.82, 95% CI = −1.33, −0.31]. Income also affected ADHD through educational attainment [female: Beta = −1.08, 95% CI = −1.35, −0.83; male: Beta = −1.16, 95% CI = −1.57, −0.77; persistent: Beta = −1.48, 95% CI = −2.09, −0.94]. In the final analysis, data with heterogeneity were analyzed using IVW random effects results. The mechanism is that income will mediate the relationship between educational attainment and ADHD.
关键词	Attention deficit hyperactivity disorder Educational attainment Income Two-step Mendelian randomization study
相关链接	[Scopus记录]
收录类别	SCI ; SSCI
语种	英语
学校署名	其他
ESI学科分类	SOCIAL SCIENCES, GENERAL
Scopus记录号	2-s2.0-85185901899
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/729164
专题	南方科技大学医学院_公共卫生及应急管理学院
作者单位	1.School of Public Policy and Administration,Xi'an Jiaotong University,Xi'an,710049,China 2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 3.Department of Obstetrics and Gynecology,West China Second University Hospital of Sichuan University,Chengdu,610041,China 4.West China School of Medicine,Sichuan University,Chengdu,610041,China
推荐引用方式 GB/T 7714	Xie，Tao,Zhu，Bin,Li，Hao ran,et al. Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization[J]. Social Science and Medicine,2024,345.
APA	Xie，Tao,Zhu，Bin,Li，Hao ran,Xu，Jin feng,&Mao，Ying.(2024).Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization.Social Science and Medicine,345.
MLA	Xie，Tao,et al."Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization".Social Science and Medicine 345(2024).