Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma

Ye，Lele1; Jiang，Zhuofeng2; Zheng，Mengxia1; Pan，Kan3; Lian，Jingru2; Ju，Bing2; Liu，Xuefei2; Tang，Sangsang1; Guo，Gangqiang4; Zhang，Songfa5; Hong，Xin2,6,7; Lu，Weiguo1,5,8

2024-03-01

10.2217/epi-2023-0388

Epigenomics   影响因子和分区

1750-1911

1750-192X

Background: To explore the role of fatty acid metabolism (FAM)-related lncRNAs in the prognosis and antitumor immunity of serous ovarian cancer (SOC). Materials & methods: A SOC FAM-related lncRNA risk model was developed and evaluated by a series of analyses. Additional immune-related analyses were performed to further assess the associations between immune state, tumor microenvironment and the prognostic risk model. Results: Five lncRNAs associated with the FAM genes were found and used to create a predictive risk model. The patients with a low-risk profile exhibited favorable prognostic outcomes. Conclusion: The established prognostic risk model exhibits better predictive capabilities for the prognosis of patients with SOC and offers novel potential therapy targets for SOC.

immunotherapy lncRNAs model overall survival tumor microenvironment

SCI

英语

其他

2-s2.0-85185711746

Scopus

1.Women's Reproductive Health Laboratory of Zhejiang Province,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310006,China
2.Department of Biochemistry,School of Medicine,Southern University of Science & Technology,Shenzhen,Guangdong,518055,China
3.First Clinical College,Wenzhou Medical University,Wenzhou,Zhejiang,325035,China
4.Wenzhou Collab. Innovation Center of Gastrointestinal Cancer in Basic Research Precision Medicine,Wenzhou Key Laboratory of Cancer-related Pathogens & Immunity,Department of Microbiology & Immunology,Institute of Molecular Virology & Immunology,Institute of Tropical Medicine,School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,325035,China
5.Department of Gynecologic Oncology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310006,China
6.Key University Laboratory of Metabolism & Health of Guangdong,Southern University of Science & Technology,Shenzhen,Guangdong,518055,China
7.Guangdong Provincial Key Laboratory of Cell Microenvironment & Disease Research,Southern University of Science & Technology,Shenzhen,Guangdong,518055,China
8.Center of Uterine Cancer Diagnosis & Therapy of Zhejiang Province,Hangzhou,Zhejiang,310006,China

Ye，Lele,Jiang，Zhuofeng,Zheng，Mengxia,et al. Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma[J]. Epigenomics,2024,16(5):309-329.

Ye，Lele.,Jiang，Zhuofeng.,Zheng，Mengxia.,Pan，Kan.,Lian，Jingru.,...&Lu，Weiguo.(2024).Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma.Epigenomics,16(5),309-329.

Ye，Lele,et al."Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma".Epigenomics 16.5(2024):309-329.