| 题名 | Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat |
| 作者 | |
| 通讯作者 | Hu，Shijun; Chen，Xi; Chang，Lei; Zhang，Wensheng |
| 共同第一作者 | Ye，Ying; Xie，Wenyan; Ma，Zhaoru |
| 发表日期 | 2024-02-09
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| DOI | |
| 发表期刊 | |
| EISSN | 2058-7716
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| 卷号 | 10期号:1 |
| 摘要 | Embryonic stem cells (ESCs) exhibit unique attributes of boundless self-renewal and pluripotency, making them invaluable for fundamental investigations and clinical endeavors. Previous examinations of microgravity effects on ESC self-renewal and differentiation have predominantly maintained a descriptive nature, constrained by limited experimental opportunities and techniques. In this investigation, we present compelling evidence derived from murine and human ESCs, demonstrating that simulated microgravity (SMG)-induced stress significantly impacts self-renewal and pluripotency through a previously unidentified conserved mechanism. Specifically, SMG induces the upregulation of heat shock protein genes, subsequently enhancing the expression of core pluripotency factors and activating the Wnt and/or LIF/STAT3 signaling pathways, thereby fostering ESC self-renewal. Notably, heightened Wnt pathway activity, facilitated by Tbx3 upregulation, prompts mesoendodermal differentiation in both murine and human ESCs under SMG conditions. Recognizing potential disparities between terrestrial SMG simulations and authentic microgravity, forthcoming space flight experiments are imperative to validate the impact of reduced gravity on ESC self-renewal and differentiation mechanisms. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| Scopus记录号 | 2-s2.0-85188351157
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| 来源库 | Scopus
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/741026 |
| 专题 | 生命科学学院 |
| 作者单位 | 1.Medical College of Soochow University,Suzhou,China 2.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China 3.School of Basic Medical Sciences,Binzhou Medical University,Yantai,China 4.State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin,Tianjin,300350,China 5.Institute of Blood and Marrow Transplantation,Medical College of Soochow University,Suzhou,China 6.School of Biology and Basic Medical Sciences,Medical College of Soochow University,Suzhou,China 7.Centre of Reproduction,Development and Aging,Faculty of Health Sciences,University of Macau,Taipa,SAR,Macao 8.Department of Cardiovascular Surgery of the First Affiliated Hospital & amp; Institute for Cardiovascular Science,Collaborative Innovation Center of Hematology,State Key Laboratory of Radiation Medicine and Protection,Medical College of Soochow University,Suzhou,215000,China 9.Department of Biomedical Engineering and Center for Biotechnology and Interdisciplinary Studies,Rensselaer Polytechnic Institute,Troy,12180,United States 10.State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection,Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Jiangsu Province International Joint Laboratory For Regeneration Medicine,Medical College of Soochow University,Suzhou,China |
| 通讯作者单位 | 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Ye，Ying,Xie，Wenyan,Ma，Zhaoru,et al. Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat[J]. Cell Death Discovery,2024,10(1).
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| APA |
Ye，Ying.,Xie，Wenyan.,Ma，Zhaoru.,Wang，Xuepeng.,Wen，Yi.,...&Zhang，Wensheng.(2024).Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat.Cell Death Discovery,10(1).
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| MLA |
Ye，Ying,et al."Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat".Cell Death Discovery 10.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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