Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders

Iqbal，Javed1; Huang，Geng Di1; Xue，Yan Xue4; Yang，Mei1,2,3; Jia，Xiao Jian1,2,3

2024-12-01

10.1007/s11033-024-09374-z

Molecular Biology Reports   影响因子和分区

0301-4851

1573-4978

Estrogen regulates a wide range of neuronal functions in the brain, such as dendritic spine formation, remodeling of synaptic plasticity, cognition, neurotransmission, and neurodevelopment. Estrogen interacts with intracellular estrogen receptors (ERs) and membrane-bound ERs to produce its effect via genomic and non-genomic pathways. Any alterations in these pathways affect the number, size, and shape of dendritic spines in neurons associated with psychiatric diseases. Increasing evidence suggests that estrogen fluctuation causes changes in dendritic spine density, morphology, and synapse numbers of excitatory and inhibitory neurons differently in males and females. In this review, we discuss the role of estrogen hormone in rodents and humans based on sex differences. First, we explain estrogen role in learning and memory and show that a high estrogen level alleviates the deficits in learning and memory. Secondly, we point out that estrogen produces a striking difference in emotional memories in men and women, which leads them to display sex-specific differences in underlying neuronal signaling. Lastly, we discuss that fluctuations in estrogen levels in men and women are related to neuropsychiatric disorders, including schizophrenia, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BPD), major depressive disorder (MDD), substance use disorder (SUD), and anxiety disorders.

Dendritic spines Drug addiction Estrogen Memory

SCI

英语

通讯

MOLECULAR BIOLOGY & GENETICS

2-s2.0-85187531881

Scopus

1.Department of Addiction Medicine,Shenzhen Clinical Research Center for Mental Disorders,Shenzhen Kangning Hospital & amp; Shenzhen Mental Health Center,Shenzhen,No. 77 Zhenbi Road, Pingshan District, Guangdong,518118,China
2.Clinical College of Mental Health,Shenzhen University Health Science Center,Shenzhen,China
3.Affiliated Mental Health Center,Southern University of Science and Technology,Shenzhen,China
4.National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence,Peking University,Beijing,China

Iqbal，Javed,Huang，Geng Di,Xue，Yan Xue,et al. Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders[J]. Molecular Biology Reports,2024,51(1).

Iqbal，Javed,Huang，Geng Di,Xue，Yan Xue,Yang，Mei,&Jia，Xiao Jian.(2024).Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular Biology Reports,51(1).

Iqbal，Javed,et al."Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders".Molecular Biology Reports 51.1(2024).