Association of hospital-treated infectious diseases and infection burden with cardiovascular diseases and life expectancy

Zheng，Jiazhen1; Ni，Can1; Lee，S. W.Ricky1; Li，Fu Rong2,3; Huang，Jinghan4,5; Zhou，Rui6; Huang，Yining6; Lip，Gregory Y.H.7,8; Wu，Xianbo6; Tang，Shaojun1,9

2024-05-01

10.1111/joim.13780

Journal of Internal Medicine   影响因子和分区

0954-6820

1365-2796

Background: The association of a broad spectrum of infectious diseases with cardiovascular outcomes remains unclear. Objectives: We aim to provide the cardiovascular risk profiles associated with a wide range of infectious diseases and explore the extent to which infections reduce life expectancy. Methods: We ascertained exposure to 900+ infectious diseases before cardiovascular disease (CVD) onset in 453,102 participants from the UK Biobank study. Time-varying Cox proportional hazard models were used. Life table was used to estimate the life expectancy of individuals aged ≥50 with different levels of infection burden (defined as the number of infection episodes over time and the number of co-occurring infections). Results: Infectious diseases were associated with a greater risk of CVD events (adjusted HR [aHR] 1.79 [95% confidence interval {CI} 1.74–1.83]). For type-specific analysis, bacterial infection with sepsis had the strongest risk of CVD events [aHR 4.76 (4.35–5.20)]. For site-specific analysis, heart and circulation infections posed the greatest risk of CVD events [aHR 4.95 (95% CI 3.77–6.50)], whereas noncardiac infections also showed excess risk [1.77 (1.72–1.81)]. Synergistic interactions were observed between infections and genetic risk score. A dose–response relationship was found between infection burden and CVD risks (p-trend <0.001). Infection burden >1 led to a CVD-related life loss at age 50 by 9.3 years [95% CI 8.6–10.3]) for men and 6.6 years [5.5–7.8] for women. Conclusions: The magnitude of the infection-CVD association showed specificity in sex, pathogen type, infection burden, and infection site. High genetic risk and infection synergistically increased the CVD risk.

cardiovascular diseases genetic risk scores infection burden infectious diseases life expectancy

SCI

英语

其他

CLINICAL MEDICINE

2-s2.0-85189541434

Scopus

1.Bioscience and Biomedical Engineering Thrust,Systems Hub,The Hong Kong University of Science and Technology (Guangzhou),Guangzhou,Guangdong,China
2.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Southern University of Science and Technology,Shenzhen,China
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
4.Biomedical Genetics Section,School of Medicine,Boston University,Boston,United States
5.Department of Chemical Pathology,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong
6.Department of Epidemiology,School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research),Southern Medical University,Guangzhou,Guangdong,China
7.Liverpool Centre for Cardiovascular Science,University of Liverpool,Liverpool John Moores University,Liverpool Heart and Chest Hospital,Liverpool,United Kingdom
8.Department of Clinical Medicine,Danish Center for Clinical Health Services Research,Aalborg University,Aalborg,Denmark
9.Division of Emerging Interdisciplinary Areas,The Hong Kong University of Science and Technology,Clear Water Bay,Hong Kong

Zheng，Jiazhen,Ni，Can,Lee，S. W.Ricky,et al. Association of hospital-treated infectious diseases and infection burden with cardiovascular diseases and life expectancy[J]. Journal of Internal Medicine,2024,295(5):679-694.

Zheng，Jiazhen.,Ni，Can.,Lee，S. W.Ricky.,Li，Fu Rong.,Huang，Jinghan.,...&Tang，Shaojun.(2024).Association of hospital-treated infectious diseases and infection burden with cardiovascular diseases and life expectancy.Journal of Internal Medicine,295(5),679-694.

Zheng，Jiazhen,et al."Association of hospital-treated infectious diseases and infection burden with cardiovascular diseases and life expectancy".Journal of Internal Medicine 295.5(2024):679-694.