Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice

Su，Tingting1; Shen，Haitao1; He，Mengyuan1; Yang，Shanshan2; Gong，Xue1; Huang，Ce2; Guo，Liuling2; Wang，Hao2; Feng，Shengyu2; Mi，Taotao2; Zhao，Meili2; Liu，Qing2; Huo，Fengjiao2; Zhu，Jian Kang3; Zhu，Jianbo1; Li，Hongbin1; Liu，Hailiang1,2,3

2024-12-01

10.1186/s12979-024-00436-1

Immunity and Ageing   影响因子和分区

1742-4933

Background: Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing activities. It has been shown to effectively alleviate neurodegenerative diseases and enhance cognitive functions in various models. The immune system has been implicated in the regulation of brain function and cognitive abilities. However, it remains unclear whether quercetin enhances cognitive functions by interacting with the immune system. Results: In this study, middle-aged female mice were administered quercetin via tail vein injection. Quercetin increased the proportion of NK cells, without affecting T or B cells, and improved cognitive performance. Depletion of NK cells significantly reduces cognitive ability in mice. RNA-seq analysis revealed that quercetin modulated the RNA profile of hippocampal tissues in aging animals towards a more youthful state. In vitro, quercetin significantly inhibited the differentiation of LinCD117 hematopoietic stem cells into NK cells. Furthermore, quercetin promoted the proportion and maturation of NK cells by binding to the MYH9 protein. Conclusions: In summary, our findings suggest that quercetin promotes the proportion and maturation of NK cells by binding to the MYH9 protein, thereby improving cognitive performance in middle-aged mice. Graphical abstract: (Figure presented.).

Cognitive level Hematopoietic stem cells MYH9 NK cells Quercetin (PubChem CID: 5280343)

SCI

英语

通讯

2-s2.0-85192721209

Scopus

1.Key Laboratory of Xinjiang Phytomedicine Resource and Utilization of Ministry of Education,College of Life Sciences,Shihezi University,Shihezi,832003,China
2.Institute for Regenerative Medicine,State Key Laboratory of Cardiology and Medical Innovation Center,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai,200123,China
3.Institute of Advanced Biotechnology and School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Su，Tingting,Shen，Haitao,He，Mengyuan,et al. Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice[J]. Immunity and Ageing,2024,21(1).

Su，Tingting.,Shen，Haitao.,He，Mengyuan.,Yang，Shanshan.,Gong，Xue.,...&Liu，Hailiang.(2024).Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice.Immunity and Ageing,21(1).

Su，Tingting,et al."Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice".Immunity and Ageing 21.1(2024).